Results 61 to 70 of about 45,044 (305)

Ice accretion simulations on airfoils [PDF]

Progress in Flight Physics, 2017
Ice shape predictions for a NACA0012 airfoil and collection efficiency predictions for the Twin Otter airfoil are obtained and presented. The results are validated with reference numerical and experimental data. Ice accretion modeling mainly consists of four steps: flow field solution; droplet trajectory calculations; thermodynamic analyses; and ice ...
S. Özgen, N. Uğur, I. Görgϋlϋ, V. Tatar   +3 more
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Aerodynamic Performance Losses due to Ice Formation on the UAV’s Wings

Havacılık ve Uzay Teknolojileri Dergisi, 2020
Ice accretion on unmanned air vehicle’s wing modifies the initial airfoil contour and changes the aerodynamic characteristic of the wing. The aim of this research is to calculate performance losses on a wing due to the accretion of rime ice.
Durmus Sinan Körpe, Özcan Yırtıcı, Serkan Özgen   +2 more
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Influence of Ice Accretion on the Thermodynamic Performance of a Scientific Balloon: A Simulation Study

Aerospace
A scientific balloon is the ideal platform for carrying out long-duration missions for scientific research in the stratosphere. However, when a scientific balloon ascends through icy clouds and reaches supercooled droplets, there is a risk of ice ...
Qiang Liu, Lan He, Yanchu Yang, Kaibin Zhao, Tao Li, Rongchen Zhu, Yanqing Wang   +6 more
doaj   +1 more source

Ice Accretion on Wires and Anti-Icing Induced by Joule Effect [PDF]

Journal of Applied Meteorology, 1988
Abstract This study concerns both the formation of ice accreted around wires due to rotation from gravitational and aerodynamic forces, and the anti-icing induced by the Joule effect. The experiments have been carried out in an instrumented wind tunnel operating in natural conditions. The results show that the growth rate increases with the ice deposit
Personne, Pascal, Gayet, Jean-François
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Prediction of Ice Accretion on Qinling Transmission Lines Integrating Image Recognition and Numerical Simulation

南方能源建设
[Objective] Ice accretion on transmission lines is one of the common extreme meteorological risks in power systems. To enhance the safe operation of transmission lines, this study addresses key technical issues in ice accretion prediction and monitoring.
Hongliang ZHOU, Liqiang ZHANG, Xiaogang DONG, Chao ZHAO, Shengli QUAN, Lifan DONG, Lingbo MENG, Lanjun YANG   +7 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source