Results 61 to 70 of about 657,097 (236)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Experimental study of ice accretion on S826 & S832 wind turbine blade profiles [PDF]
, 2019 To optimize the aerodynamic performance and reduce production losses of wind turbine operating in icing conditions, it is necessary to better understand the ice accretion physics along wind turbine blade.
Jin, Jia Yi +3 more
core +1 more source
Ice accretion thickness prediction using flash infrared thermal imaging and BP neural networks
IET Image Processing, 2023 The present study investigated ice accretion thickness under non‐incoming flow icing conditions on the ground using an infrared thermography system that converts infrared radiation temperature.
Lu Hao +4 more
doaj +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
IET Renewable Power GenerationIce accretion poses a significant challenge, threatening the safety and operational stability of wind turbines in extreme cold weather. Accurate estimation of ice accretion is essential in minimizing this concern. Data‐driven techniques typically rely on
Shouyuan Mao +3 more
doaj +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
AerospaceA scientific balloon is the ideal platform for carrying out long-duration missions for scientific research in the stratosphere. However, when a scientific balloon ascends through icy clouds and reaches supercooled droplets, there is a risk of ice ...
Qiang Liu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Wind-tunnel investigation of icing of an inclined cylinder [PDF]
, 2010 The effects of varying the angle of wind velocity and axis of a cylindrical icing object around all of the three mutually perpendicular axes are studied experimentally.
Kollar, László E., Farzaneh, Masoud
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source