Results 51 to 60 of about 657,097 (236)

Greenland Ice Sheet Ice Slab Expansion and Thickening

Geophysical Research Letters, 2023
We use airborne accumulation radar data acquired over the Greenland Ice Sheet between 2002 and 2018 to identify changes in ice slab extent and thickness. We show that ice slabs several meters thick were already present at least as early as 2002.
N. Jullien, A. J. Tedstone, H. Machguth, N. B. Karlsson, V. Helm   +4 more
doaj   +1 more source

Application of Discrete Vortex Method with Compressibility Correction in Numerical Simulation of Ice Accretion

Hangkong gongcheng jinzhan, 2021
Discrete vortex method(DVM) is a grid-free vortex motion algorithm, which is suitable for solving unsteady problems caused by producing easily separate flow.Applying the method to the flow solution in the ice accretion process can effectively simulate ...
ZHOU Zekun, ZHOU Feng, WANG Gang
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Performance Deterioration of Pitot Tubes Caused by In-Flight Ice Accretion: A Numerical Investigation

International Journal of Aerospace Engineering, 2021
In-flight ice accretion on typical pitot-static systems is numerically investigated to reveal their performance deterioration under both rime and glaze icing.
Hao Zhang, Rui Zhao, Chih-Yung Wen
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Ice Accretion Forecast for Power Grids Based on Pangu Model and Machine Learning Correction: A Case Study on Late December 2021 in Xinjiang, China

Atmosphere
During late December 2021, an ice accretion disaster occurred in North Xinjiang, especially in the western part. It is found that the meteorological conditions suitable for the occurrence of ice accretion disasters are when the temperature is between −14
Yujie Li, Yang Yang, Meng Li, Mingguan Zhao, Xiaojing Yang   +4 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Research on Ice Accretion Prediction Model for Wind Turbine Blades Based on Multi-Layer Perceptron Neural Network

发电技术
ObjectivesIn cold regions, the icing problem on wind turbine blades significantly reduces power generation efficiency and increases safety risks, making accurate icing prediction technology crucial. To improve the accuracy of ice accretion prediction for
HAN Bin, ZENG Zhixiang, KONG Fanxin, XIE Nan, LIU Zhiqiang   +4 more
doaj   +1 more source