Results 41 to 50 of about 45,044 (305)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Numerical simulations of ice crystal icing within a 1.5-stage compressor in an aero-engine

open access: yesCase Studies in Thermal Engineering
Ice crystal icing within aircraft engines at high altitudes significantly impacts safe operation. Due to the complexity of the structure and the thermodynamic conditions, gaining a comprehensive understanding of ice crystal icing presents a considerable ...
Ping Huang   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Detailed atmospheric ice accretion surface measurement using micro‐computed tomography

open access: yesAtmospheric Science Letters, 2020
Surfaces exposed to atmospheric cold temperature and humid environments are prone to ice accretion. Airplanes, electrical power transmission cables, and wind turbines are typical examples for which icing has to be considered.
Juan S. Velandia, Stephan E. Bansmer
doaj   +1 more source

UAV Icing: Ice Accretion Experiments and Validation [PDF]

open access: yesSAE Technical Paper Series, 2019
<div class="section abstract"><div class="htmlview paragraph">Atmospheric icing is a key challenge to the operational envelope of medium-sized fixed-wing UAVs. Today, several numeric icing codes exist, that all have been developed for general aviation applications.
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

CO2 Ice toward Low-luminosity, Embedded Protostars: Evidence for Episodic Mass Accretion via Chemical History [PDF]

open access: yes, 2012
We present Spitzer IRS spectroscopy of CO2 ice bending mode spectra at 15.2 micrometer toward 19 young stellar objects with luminosity lower than 1 Lsun (3 with luminosity lower than 0.1 Lsun). Ice on dust grain surfaces can encode the history of heating
André   +48 more
core   +2 more sources

Ice crystals accretion capabilities of ONERA’s 3D icing suite

open access: yesAIAA AVIATION 2022 Forum, 2022
In the framework of the MUSIC-haic European project, the ONERA 3D accretion solver Film has been enhanced with ICI (Ice Crystal Icing) capabilities. These new features target different phenomena such as ice layer porosity, erosion due to ice crystals impacts, and also heat transfers with the solid surface.
Laurent, Claire   +4 more
openaire   +2 more sources

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