Results 41 to 50 of about 597,547 (288)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Information and Communication Technologies (ICT) for the intelligent operation of building energy systems: design, implementation and evaluation in a living lab

Energy Informatics
Successful adaptation to climate change requires resilient, reliable, and efficient energy systems. To unlock energy efficiency potentials in buildings, an intelligent, user-centered approach is vital.
Florian Redder, Philipp Althaus, Eziama Ubachukwu, Maximilian Mork, Sascha Johnen, Christian Küpper, Paul Lieberenz, Marieluise Oden, Lidia Westphal, Thomas Storek, André Xhonneux, Dirk Müller   +11 more
doaj   +1 more source

Incorporation of lumped IVOC emissions into the ORACLE model (V1.1): a multi-product framework for assessing global SOA formation from internal combustion engines [PDF]

Geoscientific Model Development
Secondary organic aerosol (SOA) is a major component of particulate matter but is often underpredicted in chemistry climate models. Recent advances in measuring and resolving the chemically complex structure of intermediate volatile organic compounds ...
S. M. C. Scholz, V. A. Karydis, G. I. Gkatzelis, H. Fuchs, H. Fuchs, S. N. Pandis, S. N. Pandis, A. P. Tsimpidi   +7 more
doaj   +1 more source

Simulating higher-order fabric structure in a coupled, anisotropic ice-flow model: application to Dome C

Journal of Glaciology, 2023
Ice-crystal fabric can induce mechanical anisotropy that significantly affects flow, but ice-flow models generally do not include fabric development or its effect upon flow.
David A. Lilien, Nicholas M. Rathmann, Christine S. Hvidberg, Aslak Grinsted, M. Reza Ershadi, Reinhard Drews, Dorthe Dahl-Jensen   +6 more
doaj   +1 more source

Direct Injection Liquid Chromatography High-Resolution Mass Spectrometry for Determination of Primary and Secondary Terrestrial and Marine Biomarkers in Ice Cores [PDF]

, 2019
Many atmospheric organic compounds are long-lived enough to be transported from their sources to polar regions and high mountain environments where they can be trapped in ice archives.
Bogialli, S., Giorio, C., Kalberer, M., King, A. C. F., Roverso, M., Schwikowski, M., Tapparo, A., Thomas, E., Wolff, E.   +8 more
core   +1 more source

Enhancing Low‐Temperature Performance of Sodium‐Ion Batteries via Anion‐Solvent Interactions

Advanced Functional Materials, EarlyView.
DOL is introduced into electrolytes as a co‐solvent, increasing slat solubility, ion conductivity, and the de‐solvent process, and forming an anion‐rich solvent shell due to its high interaction with anion. With the above virtues, the batteries using this electrolyte exhibit excellent cycling stability at low temperatures. Abstract Sodium‐ion batteries
Cheng Zheng, Qian Yao, Yanan Sun, Hongyu Lv, Zhongchao Bai, Guoliang Zhang, Nana Wang, Jian Yang   +7 more
wiley   +1 more source

A microphysics guide to cirrus – Part 3: Occurrence patterns of cloud particles [PDF]

Atmospheric Chemistry and Physics
Cloud particle size distributions (PSDs) are crucial in determining the clouds physical and optical properties and hence their radiative feedback to the climate.
M. Krämer, M. Krämer, N. Spelten, C. Rolf, R. Spang   +4 more
doaj   +1 more source

A first chronology for the North Greenland Eemian Ice Drilling (NEEM) ice core [PDF]

Climate of the Past, 2013
A stratigraphy-based chronology for the North Greenland Eemian Ice Drilling (NEEM) ice core has been derived by transferring the annual layer counted Greenland Ice Core Chronology 2005 (GICC05) and its model extension (GICC05modelext) from the NGRIP core
S. O. Rasmussen, P. M. Abbott, T. Blunier, A. J. Bourne, E. Brook, S. L. Buchardt, C. Buizert, J. Chappellaz, H. B. Clausen, E. Cook, D. Dahl-Jensen, S. M. Davies, M. Guillevic, S. Kipfstuhl, T. Laepple, I. K. Seierstad, J. P. Severinghaus, J. P. Steffensen, C. Stowasser, A. Svensson, P. Vallelonga, B. M. Vinther, F. Wilhelms, M. Winstrup   +23 more
doaj   +1 more source

Earth's Energy Imbalance and Implications [PDF]

, 2011
Improving observations of ocean heat content show that Earth is absorbing more energy from the sun than it is radiating to space as heat, even during the recent solar minimum.
Hansen, James, Kharecha, Pushker, Sato, Makiko, von Schuckmann, Karina   +3 more
core   +4 more sources

Laser‐Induced Graphene from Waste Almond Shells

Advanced Functional Materials, EarlyView.
Almond shells, an abundant agricultural by‐product, are repurposed to create a fully bioderived almond shell/chitosan composite (ASC) degradable in soil. ASC is converted into laser‐induced graphene (LIG) by laser scribing and proposed as a substrate for transient electronics.
Yulia Steksova, Anna Chiara Bressi, Marina Galliani, Attilio Marino, Gianni Ciofani, Eduardo Machado‐Charry, Hilda Gomez Bernal, Alessandra Francini, Luca Sebastiani, Francesco Greco   +9 more
wiley   +1 more source