Results 81 to 90 of about 2,979,995 (245)
Rapid increase in atmospheric iodine levels in the North Atlantic since the mid-20th century
Nature Communications, 2018 Despite its chemical importance, the evolution of atmospheric iodine concentrations over time is unknown. Here, the authors show that North Atlantic atmospheric iodine levels have tripled since 1950, and propose ozone pollution and enhanced biological ...
Carlos A. Cuevas +14 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Geophysical Research LettersRecent observations from the ExoMars Trace Gas Orbiter (TGO) have revealed the presence of hydrogen chloride (HCl) in the martian atmosphere. HCl shows strong seasonality, primarily appearing during Mars' perihelion period before decreasing faster than ...
Paul M. Streeter +6 more
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Astronomy & AstrophysicsContext. To study interstellar gas and grain chemistry, gas-phase astrochemical models have been developed since the early 1980s and gas-grain models since the 1990s. Each published model includes various assumptions mainly for surface processes.
Wakelam V., Tu T.
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
First-principles Study Of Molecular Point Defects In Ice Ih: Interstitial Vs. Vacancy
, 2015 [No abstract available]163169Petrenko, V.F., Whitworth, R.W., (1999) The Physics of Ice, , Oxford University Press, OxfordHaas, C., (1962) Phys. Lett, 3, p. 126Mogensen, O.E., Eldrup, M., (1978) J. Glaciology, 21, p. 854Hondoh, T., Itoh, T., Higashi, A.,
Da Silva A.J.R. +3 more
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
ANNOTATED BIBLIOGRAPHY OF RUSSIAN LITERATURE ON GLACIOLOGY IN 2010
Лëд и снег, 2015 This bibliography includes 294 books and articles published mostly in 2010. Annotated books and articles relate to ten thematic sections of glaciology:1. General problems of glaciology2. Physics and chemistry of ice3. Ice in atmosphere4.
V. M. Kotlyakov +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source