Results 81 to 90 of about 3,045,189 (293)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The composition of air enclosed in natural ice [PDF]

, 1981
Die in frisch gebildetem Eis eingeschlossene Luft enthält Informationen über die Art der Prozesse, durch die das entsprechende Eis entstanden ist, sowie über Umweltbedingungen zur Zeit der Eisbildung.
Stauffer, Bernhard
core  

Ice composition evidence of marine ice transfer along the bottom of a small Antarctic Ice Shelf

Geophysical Research Letters, 1991
The existence of marine ice transfer along the underside of the Hell's Gate Ice Shelf ( Victoria Land), is indicated by an isotopic and chemical study of ice cores. Because of top surface ablation, the marine ice formed at the ice shelf‐ocean interface, ultimately appears at shelf surface.
SOUCHEZ R, MENEGHEL M, TISON J. L, LORRAIN R, RONVEAUX D, BARONI, CARLO, LOZEJ A, TABACCO I, JOUZEL J.   +8 more
openaire   +3 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Variability of the ice nuclei concentration over Central Europe [PDF]

, 2011
Die kumulative Dissertation beschäftigt sich mit der atmosphärischen Konzentration von Eiskeimen, einer Unterklasse des atmosphärischen Aerosols, die bei der Eisbildung in Wolken eine zentrale Bedeutung besitzt.
Klein, Holger
core  

Freeze Concentration, Supercooling, and Glass Formation in Perchlorate and Chlorate Brines: Habitability in Salty Martian Ice

The Planetary Science Journal
Oxychlorine salts, including chlorates and perchlorates, are widespread in Martian soil. Despite this significance, key metrics influencing the rheological properties and habitability of aqueous oxychlorine systems, such as the glass transition ...
Ardith Bravenec, David C. Catling
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Optical Constants of Ices Important to Planetary Science from Laboratory Reflectance Spectroscopy

The Planetary Science Journal
Laboratory-derived optical constants are essential for identifying ices and measuring their relative abundances on solar system objects. Almost all optical constants of ices important to planetary science come from experiments with transmission ...
S. C. Tegler, W. M. Grundy, M. J. Loeffler, P. D. Tribbett, J. Hanley, A. V. Jasko, H. Dawson, A. N. Morgan, K. J. Koga, A. O. Madden-Watson, M. D. Gomez, J. K. Steckloff, G. E. Lindberg, S. P. Tan, S. M. Raposa, A. E. Engle, C. L. Thieberger, D. E. Trilling   +17 more
doaj   +1 more source