Results 61 to 70 of about 3,045,189 (293)

A study of the dynamics of the British Ice Sheet during Marine Isotope Stages 2 and 3, focusing on Heinrich Events 2 and 4 and their relationship to the North Atlantic glaciological and climatological conditions [PDF]

, 2007
A high-resolution investigation into the stratigraphy of core MD95-2006 from the Barra fan, NW Scottish continental slope has been carried out. The study focuses on key palaeoceanographic proxies (percentage Neogloboquadrina pachyderma (s), planktonic ...
Leigh, Sasha Naomi Bharier
core   +2 more sources

Prospects for the application of ice composite materials for the construction of ice crossings

Arctic: Ecology and Economy, 2022
Ice as a structural material is considered as a pavement material, a substitute for traditional building materials in the northern construction and climatic zone. Improvement in ice strength can be achieved by macro- and micro-reinforcement. In the North and the Arctic conditions, materials of natural origin from local raw materials are economically ...
A.S. Syromyatnikova, L.K. Fedorova
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The importance of crystalline phases in ice nucleation by volcanic ash [PDF]

Atmospheric Chemistry and Physics, 2019
Volcanic ash is known to nucleate ice when immersed in supercooled water droplets. This process may impact the properties and dynamics of the eruption plume and cloud as well as those of meteorological clouds once the ash is dispersed in the atmosphere ...
E. C. Maters, D. B. Dingwell, C. Cimarelli, D. Müller, T. F. Whale, T. F. Whale, B. J. Murray   +6 more
doaj   +1 more source

Composition of Ices in Low‐Mass Extrasolar Planets [PDF]

The Astrophysical Journal, 2008
Accepted for publication in The Astrophysical ...
Marboeuf, U., Mousis, O., Ehrenreich, D., Alibert, Yann, Cassan, A., Wakelam, Valentine, Beaulieu, J.-P.   +6 more
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Compositional and Mineralogical Effects on Ice Nucleation Activity of Volcanic Ash

Atmosphere, 2018
Volcanic ash produced during explosive eruptions may serve as ice nuclei in the atmosphere, contributing to the occurrence of volcanic lightning due to tribocharging from ice–ice or ice–ash collisions.
Kimberly Genareau, Shelby M. Cloer, Katherine Primm, Margaret A. Tolbert, Taylor W. Woods   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source