Results 121 to 130 of about 7,279,413 (322)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Dynamical mechanism of antifreeze proteins to prevent ice growth
, 2014 The fascinating ability of algae, insects and fishes to survive at temperatures below normal freezing is realized by antifreeze proteins (AFPs). These are surface-active molecules and interact with the diffusive water/ice interface thus preventing ...
Kutschan, B., Morawetz, K., Thoms, S.
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Influence of Ice Nuclei Parameterization Schemes on the Hail Process
Advances in Meteorology, 2018 Ice nuclei are very important factors as they significantly affect the development and evolvement of convective clouds such as hail clouds. In this study, numerical simulations of hail processes in the Zhejiang Province were conducted using a mesoscale ...
Xiaoli Liu +3 more
doaj +1 more source
Chemical species spatial distribution and relationship to elevation and snow accumulation rate over the Greenland Ice Sheet [PDF]
, 1996 Major chemical species (Cl−, NO−3, SO2−4, Na+, K+, Mg2+, Ca2+) from 24 snowpits (sampled at a resolution of 3 cm, total 2995 samples) collected from northern, central, and southern Greenland were used for this investigation.
Linder, E. +4 more
core +3 more sources
A direct optical method for the study of grain boundary melting
, 2009 The structure and evolution of grain boundaries underlies the nature of polycrystalline materials. Here we describe an experimental apparatus and light reflection technique for measuring disorder at grain boundaries in optically clear material, in ...
E. S. Thomson +5 more
core +1 more source
On the assimilation of ice velocity and concentration data into large-scale sea ice models [PDF]
, 2007 Data assimilation into sea ice models designed for climate studies has started about 15 years ago. In most of the studies conducted so far, it is assumed that the improvement brought by the assimilation is straightforward.
T. Fichefet, V. Dulière
core +3 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Sea ice concentration decline in an important Adélie penguin molt area. [PDF]
Proc Natl Acad Sci U S A, 2023 Schmidt AE +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source