Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Sea ice concentration decline in an important Adélie penguin molt area. [PDF]
Proc Natl Acad Sci U S A, 2023 Schmidt AE +6 more
europepmc +1 more source
Internal waves in the Arctic : influence of ice concentration, ice roughness, and surface layer stratification [PDF]
, 2018 Author Posting. © American Geophysical Union, 2018. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution.
Cole, Sylvia T. +3 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Influence of Ice Nuclei Parameterization Schemes on the Hail Process
Advances in Meteorology, 2018 Ice nuclei are very important factors as they significantly affect the development and evolvement of convective clouds such as hail clouds. In this study, numerical simulations of hail processes in the Zhejiang Province were conducted using a mesoscale ...
Xiaoli Liu +3 more
doaj +1 more source
AI4SeaIce: selecting loss functions for automated SAR sea ice concentration charting. [PDF]
Sci Rep, 2023 Kucik A, Stokholm A.
europepmc +1 more source
Pilot study and evaluation of a SMMR-derived sea ice data base [PDF]
Data derived from the Nimbus 7 scanning multichannel microwave radiometer (SMMR) are discussed and the types of problems users have with satellite data are documented. The development of software for assessing the SMMR data is mentioned. Two case studies
Anderson, M. R. +4 more
core +1 more source
Assimilation of sea-ice concentration in a global climate model — physical and statistical aspects [PDF]
, 2012 We investigate the initialisation of Northern Hemisphere sea ice in the global climate model ECHAM5/MPI-OM by assimilating sea-ice concentration data. The analysis updates for concentration are given by Newtonian relaxation, and we discuss different ways
Jungclaus, J. H. +3 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Improvement of Arctic Sea Ice Type Concentration Retrieval From Microwave Remote Sensing Data
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingSea ice types, such as first-year ice and multiyear ice, can be discriminated based on radiometric and scattering signatures. However, changes in ice surface properties caused by processes like ice surface deformation and melt-refreeze events can lead to
Yanbing Luo +5 more
doaj +1 more source