Results 91 to 100 of about 1,498,627 (306)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A Comparison Of New Calculations Of The Yearly 10Be Production In The Earths Polar Atmosphere By Cosmic Rays With Yearly 10Be Measurements In Multiple Greenland Ice Cores Between 1939 And 1994 - A Troubling Lack Of Concordance Paper #2

, 2010
We have compared the yearly production rates of 10Be by cosmic rays in the Earths polar atmosphere over the last 50-70 years with 10Be measurements from two separate ice cores in Greenland.
Aldahan, Ansmann, Auer, Bard, Bard, Bard, Bard, Baroni, Beer, Beer, Beer, Beer, Belov, Berggren, Briffa, Cacciani, Clilverd, Cole-Dai, Delaygue, Delmas, Delmas, Delmonte, Deshler, Didier Bourlès, Edouard Bard, Elmore, Field, Field, Fischer, Fourré, Gao, Gray, Hall, Heikkila, Holton, Horiuchi, Hoyt, Jean-Robert Petit, Kovaltsov, Lal, Lal, Masarik, Masarik, Masson-Delmotte, Mavromichalaki, Mayaud, Mc Cormick, Mc Cracken, Muscheler, Mélanie Baroni, Nagai, Naik, Niemeier, Nydal, Olivier Magand, Paillard, Pedro, Pedro, Petit, Pourchet, Raisbeck, Raisbeck, Raisbeck, Robock, Steig, Stuiver, Synal, Thompson, Timmreck, Usoskin, Usoskin, Usoskin, Usoskin, Vainio, Venegas, Wagenbach, Webber, Webber, White, Whitehead, Wolff   +80 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A direct optical method for the study of grain boundary melting

, 2009
The structure and evolution of grain boundaries underlies the nature of polycrystalline materials. Here we describe an experimental apparatus and light reflection technique for measuring disorder at grain boundaries in optically clear material, in ...
E. S. Thomson, J. S. Wettlaufer, Kamb W. B., L. A. Wilen, Mader H. M., Walford M. E. R.   +5 more
core   +1 more source

Brief communication: impacts of ocean-wave-induced breakup of Antarctic sea ice via thermodynamics in a stand-alone version of the CICE sea-ice model [PDF]

, 2017
Impacts of wave-induced breakup of Antarctic sea ice on ice concentration and volume are investigated using a modified version of the CICE sea-ice model, run in standalone mode from 1979–2010.
Bennetts, L., O'Farrell, S., Uotila, P.
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The $^{12}$CO$_2$ and $^{13}$CO$_2$ Absorption Bands as Tracers of the Thermal History of Interstellar Icy Grain Mantles [PDF]

, 2018
Analyses of infrared signatures of CO$_2$ in water dominated ices in the ISM can give information on the physical state of CO$_2$ in icy grains and on the thermal history of the ices themselves. In many sources, CO$_2$ was found in the `pure' crystalline
Boogert, Adwin, Emtiaz, SM, He, Jiao, Vidali, Gianfranco   +3 more
core   +3 more sources