Results 71 to 80 of about 772,855 (261)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Sea ice concentration decline in an important Adélie penguin molt area. [PDF]
Proc Natl Acad Sci U S A, 2023 Schmidt AE +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Influence of Ice Nuclei Parameterization Schemes on the Hail Process
Advances in Meteorology, 2018 Ice nuclei are very important factors as they significantly affect the development and evolvement of convective clouds such as hail clouds. In this study, numerical simulations of hail processes in the Zhejiang Province were conducted using a mesoscale ...
Xiaoli Liu +3 more
doaj +1 more source
AI4SeaIce: selecting loss functions for automated SAR sea ice concentration charting. [PDF]
Sci Rep, 2023 Kucik A, Stokholm A.
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Improvement of Arctic Sea Ice Type Concentration Retrieval From Microwave Remote Sensing Data
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingSea ice types, such as first-year ice and multiyear ice, can be discriminated based on radiometric and scattering signatures. However, changes in ice surface properties caused by processes like ice surface deformation and melt-refreeze events can lead to
Yanbing Luo +5 more
doaj +1 more source
Author Correction: AI4SeaIce: selecting loss functions for automated SAR sea ice concentration charting. [PDF]
Sci Rep, 2023 Kucik A, Stokholm A.
europepmc +1 more source