Results 31 to 40 of about 312,748 (262)

A full Stokes ice-flow model to assist the interpretation of millennial-scale ice cores at the high-Alpine drilling site Colle Gnifetti, Swiss/Italian Alps

Journal of Glaciology, 2020
The high-Alpine ice-core drilling site Colle Gnifetti (CG), Monte Rosa, Swiss/Italian Alps, provides climate records over the last millennium and beyond.
Carlo Licciulli, Pascal Bohleber, Josef Lier, Olivier Gagliardini, Martin Hoelzle, Olaf Eisen   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Evaluating marine dust records as templates for optical dating of Oldest Ice [PDF]

Climate of the Past
The continuous ice core record extends 800 000 years into the past, covering the period of 100 000-year glacial cycles but not the transition from 40 000-year glacial cycles (the mid-Pleistocene transition, 1.2–0.7 million years ago).
J. Ng, J. Severinghaus, R. Bay, D. Tosi
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Potential to recover a record of Holocene climate and sea ice from Müller Ice Cap, Canada

Journal of Glaciology
Müller Ice Cap sits on Umingmat Nunaat (Axel Heiberg Island), Nunavut, Canada, ~ 80°N. Its high latitude and elevation suggest it experiences relatively little melt and preserves an undisturbed paleoclimate record.
David Armond Lilien, Niels Fabrin Nymand, Tamara Annina Gerber, Daniel Steinhage, Daniela Jansen, Laura Thomson, Madeline Myers, Steven Franke, Drew Taylor, Prasad Gogineni, Marcos Lemes, Bo Møllesøe Vinther, Dorthe Dahl-Jensen   +12 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

39Ar dating of cave ice combined with pollen, cryogenic calcite and radiocarbon analyses reveals late Little Ice Age origin (Leupa Ice Cave, Julian Alps)

Journal of Glaciology
High-latitude or high-altitude caves often preserve ice deposits that contain valuable signals of past climate conditions, sometimes even reflecting regional and local atmospheric variability.
Renato R. Colucci, Pascal Bohleber, Werner Aeschbach, Marc Luetscher, Margit Schwikowski, Gina E. Moseley, David Wachs, Theo Manuel Jenk, Anja Eichler, Andrea Securo, Lawrence R. Edwards, Sonia Manzan, Dirk L. Hoffmann, Markus K. Oberthaler, Daniela Festi   +14 more
doaj   +1 more source

Advancing interpretation of incoherent scattering in ice-penetrating radar data used for ice core site selection [PDF]

The Cryosphere
Below the coherent layering in ice-penetrating radar data collected in Antarctica and Greenland, incoherent scattering is common. This scattering is signal, not noise, and has the potential to inform our understanding of the structure and dynamics of the
E. L. Mutter, N. Holschuh
doaj   +1 more source