Results 41 to 50 of about 312,748 (262)

Age ranges of the Tibetan ice cores with emphasis on the Chongce ice cores, western Kunlun Mountains [PDF]

The Cryosphere, 2018
An accurate chronology is the essential first step for a sound understanding of ice core records. However, dating ice cores drilled from the high-elevation glaciers is challenging and often problematic, leading to great uncertainties.
S. Hou, S. Hou, T. M. Jenk, T. M. Jenk, W. Zhang, C. Wang, S. Wu, Y. Wang, H. Pang, M. Schwikowski, M. Schwikowski   +10 more
doaj   +1 more source

Ice drilling on Skytrain Ice Rise and Sherman Island, Antarctica

Annals of Glaciology, 2021
To understand the long-term climate and glaciological evolution of the ice sheet in the region bordering the Weddell Sea, the British Antarctic Survey has undertaken a series of successful ice core projects drilling to bedrock on Berkner Island, James ...
Robert Mulvaney, Julius Rix, Scott Polfrey, Mackenzie Grieman, Carlos Martìn, Christoph Nehrbass-Ahles, Isobel Rowell, Rebecca Tuckwell, Eric Wolff   +8 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Inferring geothermal heat flux from an ice-borehole temperature profile at Law Dome, East Antarctica

Journal of Glaciology, 2020
Geothermal heat flux (GHF) is an important control on the dynamics of Antarctica's ice sheet because it controls basal melt and internal deformation. However, it is hard to estimate because of a lack of in-situ measurements.
Laura Mony, Jason L. Roberts, Jacqueline A. Halpin   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Implementation of counted layers for coherent ice core chronology [PDF]

Climate of the Past, 2015
A recent coherent chronology has been built for four Antarctic ice cores and the NorthGRIP (NGRIP) Greenland ice core (Antarctic Ice Core Chronology 2012, AICC2012) using a Bayesian approach for ice core dating (Datice).
B. Lemieux-Dudon, L. Bazin, A. Landais, H. Toyé Mahamadou Kele, M. Guillevic, P. Kindler, F. Parrenin, P. Martinerie   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A reconstructed PDO history from an ice core isotope record on the central Tibetan Plateau

npj Climate and Atmospheric Science
Ice core oxygen isotope (δ18O) records from low-latitude regions preserve high-resolution climate records in the past, yet the interpretation of these ice core δ18O records is still facing difficulty due to the uncertainty of ice core dating.
Shijie Li, Lide Tian, Zhongyin Cai, Di Wang, Lili Shao, Xiaoyi Yang, Shangjie Wang, Feng Liu, Pengbin Liang   +8 more
doaj   +1 more source

Apparent discrepancy of Tibetan ice core δ¹⁸O records may be attributed to misinterpretation of chronology [PDF]

The Cryosphere, 2019
Ice cores from the Tibetan Plateau (TP) are widely used for reconstructing past climatic and environmental conditions that extend beyond the instrumental period.
S. Hou, W. Zhang, H. Pang, S.-Y. Wu, T. M. Jenk, T. M. Jenk, M. Schwikowski, M. Schwikowski, Y. Wang   +8 more
doaj   +1 more source