Results 61 to 70 of about 347,440 (309)

50 year means of oxygen isotope data from ice core NGRIP

, 2007
Two deep ice cores from central Greenland, drilled in the 1990s, have played a key role in climate reconstructions of the Northern Hemisphere, but the oldest sections of the cores were disturbed in chronology owing to ice folding near the bedrock.
North Greenland Ice Core Project Members (7904567), North Greenland Ice Core Project Members   +1 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

39Ar dating of cave ice combined with pollen, cryogenic calcite and radiocarbon analyses reveals late Little Ice Age origin (Leupa Ice Cave, Julian Alps)

Journal of Glaciology
High-latitude or high-altitude caves often preserve ice deposits that contain valuable signals of past climate conditions, sometimes even reflecting regional and local atmospheric variability.
Renato R. Colucci, Pascal Bohleber, Werner Aeschbach, Marc Luetscher, Margit Schwikowski, Gina E. Moseley, David Wachs, Theo Manuel Jenk, Anja Eichler, Andrea Securo, Lawrence R. Edwards, Sonia Manzan, Dirk L. Hoffmann, Markus K. Oberthaler, Daniela Festi   +14 more
doaj   +1 more source

Assessing the continuity of the blue ice climate record at Patriot Hills, Horseshoe Valley, West Antarctica [PDF]

, 2016
We use high resolution Ground Penetrating Radar (GPR) to assess the continuity of the Blue Ice Area (BIA) horizontal climate record at Patriot Hills, Horseshoe Valley, West Antarctica.
Turney, Chris S. M., Turney, Chris, Nicholas R. Golledge, Golledge, NR ; https://orcid.org/, Dunning, SA, Fogwill, CJ ; https://orcid.org/, Ross, N, Hein, AS, Winter, K, Marrero, Shasta M., Winter, Kate, Marrero, SM, Hein, Andrew, Golledge, Nicholas R., Kate Winter, Dunning, Stuart A., Hein, Andrew S., Christopher J. Fogwill, Fogwill, Christopher, Fogwill, Christopher J., Hein, Andrew; id_orcid, Woodward, J, Chris S. M. Turney, Sugden, David, Bingham, RG, Andrew S. Hein, Woodward, John, Golledge, Nicholas, Sugden, DE, Ross, Neil, Marrero, Shasta, Bingham, Robert, Shasta M. Marrero, Sugden, David E., Robert G. Bingham, Dunning, Stuart, John Woodward, Turney, Chris S. M.; id_orcid, Neil Ross, David E. Sugden, Stuart A. Dunning, Bingham, Robert G., Turney, C ; https://orcid.org/   +42 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Microbial nitrogen cycling on the Greenland Ice Sheet [PDF]

, 2012
Nitrogen inputs and microbial nitrogen cycling were investigated along a 79 km transect into the Greenland Ice Sheet (GrIS) during the main ablation season in summer 2010. The depletion of dissolved nitrate and production of ammonium (relative to icemelt)
J. Telling, C. Bellas, Wadham, J.L., Hodson, A, I. Nias, Wadham, Jemma L, Tranter, Martyn, J. Cook, M. Stibal, Telling, J., Bellas, Christopher M, A. Hodson, A. M. Anesio, Hodson, A., Cook, J, Sole, A, G. Lis, Nias, Isabel, Tranter, M., Lis, G., Stibal, M, P. Nienow, Anesio, A.M., Stibal, Marek, Nienow, P, Anesio, A. M., Cook, J., Tranter, M, Anesio, Alexandre M, Stibal, M., Telling, J, Bellas, C, Bellas, C., Wadham, JL, Telling, Jon P, Anesio, AM, M. Tranter, Lis, G, Sole, A., Cook, Joe, J. L. Wadham, A. Sole, Wadham, J. L., Nias, I, Nias, I., Nienow, P.   +45 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Isotopic variations of meltwater from ice by isotopic exchange between liquid water and ice

Journal of Glaciology, 2019
Predicting the isotopic modification of ice by melting processes is important for improving the accuracy in paleoclimate reconstruction. To this end, we present results from cold room laboratory observations of changes in the isotopic ratio (D/H and 18O ...
Ji-Young Ham, Soon Do Hur, Won Sang Lee, Yeongcheol Han, Hyejung Jung, Jeonghoon Lee   +5 more
doaj   +1 more source

Apparent discrepancy of Tibetan ice core δ¹⁸O records may be attributed to misinterpretation of chronology [PDF]

The Cryosphere, 2019
Ice cores from the Tibetan Plateau (TP) are widely used for reconstructing past climatic and environmental conditions that extend beyond the instrumental period.
S. Hou, W. Zhang, H. Pang, S.-Y. Wu, T. M. Jenk, T. M. Jenk, M. Schwikowski, M. Schwikowski, Y. Wang   +8 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source