Results 61 to 70 of about 1,022,984 (305)

39Ar dating of cave ice combined with pollen, cryogenic calcite and radiocarbon analyses reveals late Little Ice Age origin (Leupa Ice Cave, Julian Alps)

Journal of Glaciology
High-latitude or high-altitude caves often preserve ice deposits that contain valuable signals of past climate conditions, sometimes even reflecting regional and local atmospheric variability.
Renato R. Colucci, Pascal Bohleber, Werner Aeschbach, Marc Luetscher, Margit Schwikowski, Gina E. Moseley, David Wachs, Theo Manuel Jenk, Anja Eichler, Andrea Securo, Lawrence R. Edwards, Sonia Manzan, Dirk L. Hoffmann, Markus K. Oberthaler, Daniela Festi   +14 more
doaj   +1 more source

Ice drilling on Skytrain Ice Rise and Sherman Island, Antarctica

Annals of Glaciology, 2021
To understand the long-term climate and glaciological evolution of the ice sheet in the region bordering the Weddell Sea, the British Antarctic Survey has undertaken a series of successful ice core projects drilling to bedrock on Berkner Island, James ...
Robert Mulvaney, Julius Rix, Scott Polfrey, Mackenzie Grieman, Carlos Martìn, Christoph Nehrbass-Ahles, Isobel Rowell, Rebecca Tuckwell, Eric Wolff   +8 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Advancing interpretation of incoherent scattering in ice-penetrating radar data used for ice core site selection [PDF]

The Cryosphere
Below the coherent layering in ice-penetrating radar data collected in Antarctica and Greenland, incoherent scattering is common. This scattering is signal, not noise, and has the potential to inform our understanding of the structure and dynamics of the
E. L. Mutter, N. Holschuh
doaj   +1 more source

Apparent discrepancy of Tibetan ice core δ¹⁸O records may be attributed to misinterpretation of chronology [PDF]

The Cryosphere, 2019
Ice cores from the Tibetan Plateau (TP) are widely used for reconstructing past climatic and environmental conditions that extend beyond the instrumental period.
S. Hou, W. Zhang, H. Pang, S.-Y. Wu, T. M. Jenk, T. M. Jenk, M. Schwikowski, M. Schwikowski, Y. Wang   +8 more
doaj   +1 more source

Modeling of the northern hemisphere ice sheets during the last glacial cycle and glaciological sensitivity [PDF]

, 2005
We present a new three-dimensional thermomechanically coupled ice sheet model of the northern hemisphere to reconstruct the Quaternary ice sheets during the last glacial cycle.
Huybrechts, Philippe, Zweck, C.
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

A reconstructed PDO history from an ice core isotope record on the central Tibetan Plateau

npj Climate and Atmospheric Science
Ice core oxygen isotope (δ18O) records from low-latitude regions preserve high-resolution climate records in the past, yet the interpretation of these ice core δ18O records is still facing difficulty due to the uncertainty of ice core dating.
Shijie Li, Lide Tian, Zhongyin Cai, Di Wang, Lili Shao, Xiaoyi Yang, Shangjie Wang, Feng Liu, Pengbin Liang   +8 more
doaj   +1 more source