Results 61 to 70 of about 3,287,043 (305)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A system for analysis of H₂ and Ne in polar ice core samples [PDF]

Atmospheric Measurement Techniques
This paper describes instrumentation and procedures developed to measure H2 and Ne in polar ice core samples. Gases are extracted from ice core samples by melting under vacuum.
E. S. Saltzman, E. S. Saltzman, M. H. Miranda, J. D. Patterson, M. Aydin   +4 more
doaj   +1 more source

Apparent discrepancy of Tibetan ice core δ¹⁸O records may be attributed to misinterpretation of chronology [PDF]

The Cryosphere, 2019
Ice cores from the Tibetan Plateau (TP) are widely used for reconstructing past climatic and environmental conditions that extend beyond the instrumental period.
S. Hou, W. Zhang, H. Pang, S.-Y. Wu, T. M. Jenk, T. M. Jenk, M. Schwikowski, M. Schwikowski, Y. Wang   +8 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

39Ar dating of cave ice combined with pollen, cryogenic calcite and radiocarbon analyses reveals late Little Ice Age origin (Leupa Ice Cave, Julian Alps)

Journal of Glaciology
High-latitude or high-altitude caves often preserve ice deposits that contain valuable signals of past climate conditions, sometimes even reflecting regional and local atmospheric variability.
Renato R. Colucci, Pascal Bohleber, Werner Aeschbach, Marc Luetscher, Margit Schwikowski, Gina E. Moseley, David Wachs, Theo Manuel Jenk, Anja Eichler, Andrea Securo, Lawrence R. Edwards, Sonia Manzan, Dirk L. Hoffmann, Markus K. Oberthaler, Daniela Festi   +14 more
doaj   +1 more source

Effects of ENSO on the major ion record of a Qomolangma (Mount Everest) ice core

Annals of Glaciology, 2016
Correlations between a 1000 year record of the major ions in a 108.83 m ice core from East Rongbuk Glacier (28°01’N, 86°58’E; 6518ma.s.l.) on the northeast slope of Qomolangma (Mount Everest) and the Southern Oscillation Index (SOI) were examined to ...
Hao Xu, Shugui Hou, Hongxi Pang, Chaomin Wang   +3 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

A reconstructed PDO history from an ice core isotope record on the central Tibetan Plateau

npj Climate and Atmospheric Science
Ice core oxygen isotope (δ18O) records from low-latitude regions preserve high-resolution climate records in the past, yet the interpretation of these ice core δ18O records is still facing difficulty due to the uncertainty of ice core dating.
Shijie Li, Lide Tian, Zhongyin Cai, Di Wang, Lili Shao, Xiaoyi Yang, Shangjie Wang, Feng Liu, Pengbin Liang   +8 more
doaj   +1 more source

Basal debris of the NEEM ice core, Greenland: a window into sub-ice-sheet geology, basal ice processes and ice-sheet oscillations

Journal of Glaciology, 2023
We present new data from the debris-rich basal ice layers of the NEEM ice core (NW Greenland). Using mineralogical observations, SEM imagery, geochemical data from silicates (meteoric 10Be, εNd, 87Sr/86Sr) and organic material (C/N, δ13C), we ...
Pierre-Henri Blard, Marie Protin, Jean-Louis Tison, François Fripiat, Dorthe Dahl-Jensen, Jørgen P. Steffensen, William C. Mahaney, Paul R. Bierman, Andrew J. Christ, Lee B. Corbett, Vinciane Debaille, Thomas Rigaudier, Philippe Claeys, ASTER Team   +13 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source