Results 81 to 90 of about 1,022,984 (305)

High-throughput sequencing of fungal communities across the perennial ice block of Scărișoara Ice Cave

Annals of Glaciology, 2018
This survey presents the first high-throughput characterisation of fungal distribution based on ITS2 Illumina sequencing of uncultured microbiome from a 1500 years old perennial ice deposit in Scărișoara Ice Cave, Romania.
Antonio Mondini, Jonathan Donhauser, Corina Itcus, Constantin Marin, Aurel Perșoiu, Paris Lavin, Beat Frey, Cristina Purcarea   +7 more
doaj   +1 more source

A 200-year 210Pb record from Greenland [PDF]

, 1997
A continuous profile of 210Pb activity extending back to 1766 has been developed for a firn/ice core collected at Site D in central Greenland in 1984. Unexpectedly high activities of 210Pb were found at the base of this core (0.032 pCi kg−1 in samples ...
Clausen, Crozaz, Crozaz, Crozaz, Dibb, Dibb, Finkel, Gromet, Gunten, Gäggeler, Henrik B. Clausen, Jack E. Dibb, Lachenbruch, Laj, Mayewski, Mayewski, Mayewski, McCall, Neftel, Nijampurkar, Robbins, Sanak, Steffensen   +22 more
core   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Anomaly Detection in Paleoclimate Records using Permutation Entropy [PDF]

, 2018
Permutation entropy techniques can be useful in identifying anomalies in paleoclimate data records, including noise, outliers, and post-processing issues. We demonstrate this using weighted and unweighted permutation entropy of water-isotope records in a
Bradley, Elizabeth, Garland, Joshua, Jones, Tyler R., Morris, Valerie, Neuder, Michael, White, James W. C.   +5 more
core   +3 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

The origin of green icebergs in Antarctica [PDF]

, 1992
A comparison of samples from a translucent green iceberg with a core from the Ronne Ice Shelf revealed an excellent agreement in isotopic composition, crystal structure, and incorporated sediment particles.
Amos, Betts, Budd, Determann, Determann, Dieckmann, Dieckmann, Engelhardt, G. Dieckmann, Garrison, H. Hellmer, H. Oerter, Hellmer, J. Kipfstuhl, Jacobs, Jeffries, Jenkins, Kempema, Kipfstuhl, Kottmeier, Lee, Lewis, Morgan, Moulton, Oerter, Robin, Robin, Souchez, Swithinbank, Thomas, Thyssen, Vinje, W. Graf, Weeks, Zotikov   +34 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

An Evaluation of Antarctic Ice Core Nitrate Records as a Proxy for Solar Activity

Earth and Space Science
Nitrate (NO3−) deposition in polar ice sheets archives valuable information on past solar activity. However, interpretation of Antarctic ice core NO3− records as a proxy for past solar activity remains challenging due to multiple sources and processes ...
C. M. Laluraj, Rahaman Waliur, Thamban Meloth   +2 more
doaj   +1 more source

Simulating ice core 10Be on the glacial–interglacial timescale [PDF]

, 2015
10Be ice core measurements are an important tool for paleoclimate research, e.g., allowing for the reconstruction of past solar activity or changes in the geomagnetic dipole field.
Christl, Mark J, Dibb, Jack E., Elsasser, C, Kipfstuhl, S, Levin, I, Seietstad, I K, Stanzick, A, Wagenbach, D, Wallner, A, Wershofen, H   +9 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source