Results 81 to 90 of about 2,872,579 (294)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

An assessment of key model parametric uncertainties in projections of Greenland Ice Sheet behavior [PDF]

, 2012
Lack of knowledge about the values of ice sheet model input parameters introduces substantial uncertainty into projections of Greenland Ice Sheet contributions to future sea level rise.
Stone, Emma J., N. Kirchner, K. Keller, Keller, K., Greve, Ralf, Applegate, P. J., Greve, R., R. Greve, Keller, Klaus, Kirchner, N., Applegate, Patrick J.,, Applegate, Patrick J., Kirchner, Nina, Stone, EJ, Kirchner, Nina,, E. J. Stone, Stone, E. J., P. J. Applegate   +17 more
core   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Were the Larsemann Hills ice-free through the last Glacial Maximum? [PDF]

, 2001
Lake sediments in the Larsemann Hills contain a great diversity of biological and physical markers from which past environments can be inferred. In order to determine the timing of environmental changes it is essential to have accurate dating of ...
Noon, P.E., Verleyen, E., Gore, D. B., Noon, P. E., Bryant, C.L., Sabbe, K, Ellis-Evans, JC, Wood, P. B., Noon, PE, Appleby, P., Vyverman, W, Gilmour, M, Bryant, C. L., Gore, D.B., Jones, V.J., Appleby, P, Hodgson, D.A., Gore, DB, Hodgson, D. A., Bryant, CL, Verleyen, Elie, Jones, VJ, Sabbe, Koen, Wood, PB, Vyverman, Wim, Sabbe, K., Ellis-Evans, J. C., Hodgson, DA, Vyverman, W., Jones, V. J., Wood, P.B., Verleyen, E, Gilmour, M., Ellis-Evans, J.C., D.A. Hodgson, J.C. Ellis-Evans, W. Vyverman, P.E. Noon, E. Verleyen, P. Appleby, D.B. Gore, C.L. Bryant, K. Sabbe, V.J. Jones, P.B. Wood, M. Gilmour   +45 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

In search of an ice core signal to differentiate between source-driven and sink-driven changes in atmospheric methane [PDF]

, 2011
The concentration of atmospheric methane increased from around 360 ppbv at the last glacial maximum (similar to 20 ka before present) to about 700 ppbv in the pre-industrial era (similar to 200 years before present).
Levine, J. G., Hutterli, M. A., Wild, O., Wolff, E. W., Pyle, J. A., Carver, G. D., Jones, A. E.   +6 more
core   +4 more sources

Employing X-Ray computed tomography for the analysis of intact ice core sections

, 2022
Ice core studies are crucial for understanding past climatic events. Currently a wide range of methods is available for studying ice cores. However, most of the methods have disadvantages related to the destruction of samples and their melting during the
Александра Хайрединова Гаяровна; Московский государственный университет имени М.В. Ломоносова Институт географии РАН, Алексей Хомяк Николаевич; Московский государственный университет имени М.В. Ломоносова, Станислав Кутузов Сергеевич; Институт географии РАН, Владимир Михаленко Николаевич; Институт географии РАН, Дмитрий Корост Вячиславович; Московский государственный университет имени М.В. Ломоносова   +4 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

An Evaluation of Antarctic Ice Core Nitrate Records as a Proxy for Solar Activity

Earth and Space Science
Nitrate (NO3−) deposition in polar ice sheets archives valuable information on past solar activity. However, interpretation of Antarctic ice core NO3− records as a proxy for past solar activity remains challenging due to multiple sources and processes ...
C. M. Laluraj, Rahaman Waliur, Thamban Meloth   +2 more
doaj   +1 more source

Decadal migration of Dome C inferred by global navigation satellite system measurements

Journal of Glaciology
Understanding the behaviour of domes under both contemporary and historical environmental conditions is essential to facilitate the study of dome-divide dynamics and the interpretation of ice core records.
Luca Vittuari, Antonio Zanutta, Stefano Gandolfi, Leonardo Martelli, Catherine Ritz, Stefano Urbini, Massimo Frezzotti   +6 more
doaj   +1 more source