Results 81 to 90 of about 347,440 (309)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

High-throughput sequencing of fungal communities across the perennial ice block of Scărișoara Ice Cave

Annals of Glaciology, 2018
This survey presents the first high-throughput characterisation of fungal distribution based on ITS2 Illumina sequencing of uncultured microbiome from a 1500 years old perennial ice deposit in Scărișoara Ice Cave, Romania.
Antonio Mondini, Jonathan Donhauser, Corina Itcus, Constantin Marin, Aurel Perșoiu, Paris Lavin, Beat Frey, Cristina Purcarea   +7 more
doaj   +1 more source

Reconstruction of past atmospheric CO2 concentrations by ice core analyses [PDF]

, 2000
International Symposium on Physics of Ice Core Records.
Stauffer, Bernhard, Jürg, Tschumi, Tschumi, J.   +2 more
core  

Employing X-Ray computed tomography for the analysis of intact ice core sections

, 2022
Ice core studies are crucial for understanding past climatic events. Currently a wide range of methods is available for studying ice cores. However, most of the methods have disadvantages related to the destruction of samples and their melting during the
Александра Хайрединова Гаяровна; Московский государственный университет имени М.В. Ломоносова Институт географии РАН, Алексей Хомяк Николаевич; Московский государственный университет имени М.В. Ломоносова, Станислав Кутузов Сергеевич; Институт географии РАН, Владимир Михаленко Николаевич; Институт географии РАН, Дмитрий Корост Вячиславович; Московский государственный университет имени М.В. Ломоносова   +4 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Ice core reconstruction of sea ice change in the Amundsen‐Ross Seas since 1702 A.D.

Geophysical Research Letters, 2016
Antarctic sea ice has been increasing in recent decades, but with strong regional differences in the expression of sea ice change. Declining sea ice in the Bellingshausen Sea since 1979 (the satellite era) has been linked to the observed warming on the ...
Elizabeth R. Thomas, Nerilie J. Abram
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

record between 40 and 8 kyr B.P. from the Greenland Ice Core Project ice core

, 1997
CO2 ice-core records show an increase in the atmospheric concentration of 80–100 parts per million by volume (ppmv) from the last glacial maximum (LGM) to the early Holocene.
J. M. Barnola, Raynaud, D., D. Raynaud, B. Stauffer, J. Tschumi, Fuchs, A., Tschumi, J., M. Anklin, J. Schwander, Schwander, J., Anklin, M., A. Fuchs, Barnola, J.M., Stauffer, B.   +13 more
core   +1 more source

Switch-off of a major enhanced ice flow unit in East Antarctica [PDF]

, 2006
The East Antarctic Ice Sheet (EAIS) is the largest reservoir of ice on the planet by an order of magnitude. Compared with the West Antarctic Ice Sheet (WAIS), it is traditionally considered to be relatively stable, with only minor adjustments to its ...
Corr, Hugh F.J., Rippin, David M., Siegert, MJ, Bamber, JL, Vaughan, DG, Bamber, Jonathan L., Corr, HFJ, Vaughan, David G., Corr, Hugh F. J., Siegert, Martin J., Rippin, DM   +10 more
core   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source