Results 71 to 80 of about 2,872,579 (294)

50 year means of oxygen isotope data from ice core NGRIP

, 2007
Two deep ice cores from central Greenland, drilled in the 1990s, have played a key role in climate reconstructions of the Northern Hemisphere, but the oldest sections of the cores were disturbed in chronology owing to ice folding near the bedrock.
North Greenland Ice Core Project Members (7904567), North Greenland Ice Core Project Members   +1 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

High-throughput sequencing of fungal communities across the perennial ice block of Scărișoara Ice Cave

Annals of Glaciology, 2018
This survey presents the first high-throughput characterisation of fungal distribution based on ITS2 Illumina sequencing of uncultured microbiome from a 1500 years old perennial ice deposit in Scărișoara Ice Cave, Romania.
Antonio Mondini, Jonathan Donhauser, Corina Itcus, Constantin Marin, Aurel Perșoiu, Paris Lavin, Beat Frey, Cristina Purcarea   +7 more
doaj   +1 more source

Implementation of counted layers for coherent ice core chronology [PDF]

Climate of the Past, 2015
A recent coherent chronology has been built for four Antarctic ice cores and the NorthGRIP (NGRIP) Greenland ice core (Antarctic Ice Core Chronology 2012, AICC2012) using a Bayesian approach for ice core dating (Datice).
B. Lemieux-Dudon, L. Bazin, A. Landais, H. Toyé Mahamadou Kele, M. Guillevic, P. Kindler, F. Parrenin, P. Martinerie   +7 more
doaj   +1 more source

Mechanical anisotropy of deep ice core samples by uniaxial compression tests (scientific paper) [PDF]

, 2003
P(論文)Mechanical anisotropy of ice core samples has been observed in various uniaxial compression tests. The c-axis orientation distribution is the primary influence on the mechanical behavior of ice cores.
Shoji, Hitoshi, Hyakutake, Kinji, Miyamoto, Atsushi, Hondoh, Takeo, Shimohara, Kimiko, Narita, Hideki   +5 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Surface accumulation in Northern Central Greenland during the last 300 years

Annals of Glaciology, 2020
The internal stratigraphy of snow and ice as imaged by ground-penetrating radar may serve as a source of information on past accumulation. This study presents results from two ground-based radar surveys conducted in Greenland in 2007 and 2015 ...
Nanna B. Karlsson, Sebastian Razik, Maria Hörhold, Anna Winter, Daniel Steinhage, Tobias Binder, Olaf Eisen   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Ice core reconstruction of sea ice change in the Amundsen‐Ross Seas since 1702 A.D.

Geophysical Research Letters, 2016
Antarctic sea ice has been increasing in recent decades, but with strong regional differences in the expression of sea ice change. Declining sea ice in the Bellingshausen Sea since 1979 (the satellite era) has been linked to the observed warming on the ...
Elizabeth R. Thomas, Nerilie J. Abram
doaj   +1 more source