Results 71 to 80 of about 347,440 (309)

A reconstructed PDO history from an ice core isotope record on the central Tibetan Plateau

npj Climate and Atmospheric Science
Ice core oxygen isotope (δ18O) records from low-latitude regions preserve high-resolution climate records in the past, yet the interpretation of these ice core δ18O records is still facing difficulty due to the uncertainty of ice core dating.
Shijie Li, Lide Tian, Zhongyin Cai, Di Wang, Lili Shao, Xiaoyi Yang, Shangjie Wang, Feng Liu, Pengbin Liang   +8 more
doaj   +1 more source

Implementation of counted layers for coherent ice core chronology [PDF]

Climate of the Past, 2015
A recent coherent chronology has been built for four Antarctic ice cores and the NorthGRIP (NGRIP) Greenland ice core (Antarctic Ice Core Chronology 2012, AICC2012) using a Bayesian approach for ice core dating (Datice).
B. Lemieux-Dudon, L. Bazin, A. Landais, H. Toyé Mahamadou Kele, M. Guillevic, P. Kindler, F. Parrenin, P. Martinerie   +7 more
doaj   +1 more source

In search of an ice core signal to differentiate between source-driven and sink-driven changes in atmospheric methane [PDF]

, 2011
The concentration of atmospheric methane increased from around 360 ppbv at the last glacial maximum (∼20 ka before present) to about 700 ppbv in the pre-industrial era (∼200 years before present).
E. W. Wolff, Hutterli, M.A., Wild, O., Wolff, E. W., Pyle, J. A., Carver, G.D., J. G. Levine, A. E. Jones, J. A. Pyle, M. A. Hutterli, Wolff, E.W., Jones, A.E., Levine, J. G., Levine, J.G., Hutterli, M. A., G. D. Carver, O. Wild, Pyle, J.A., Carver, G. D., Jones, A. E.   +19 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Advancing interpretation of incoherent scattering in ice-penetrating radar data used for ice core site selection [PDF]

The Cryosphere
Below the coherent layering in ice-penetrating radar data collected in Antarctica and Greenland, incoherent scattering is common. This scattering is signal, not noise, and has the potential to inform our understanding of the structure and dynamics of the
E. L. Mutter, N. Holschuh
doaj   +1 more source

Decadal-interdecadal climate variability over Antarctica and linkages to the Tropics : analysis of ice core, instrumental, and tropical proxy data

, 2012
The Antarctic continent contains the majority of the global ice volume and plays an important role in a changing climate. The nature and causes of Antarctic climate variability are, however, poorly understood beyond interannual time scales due to the ...
Okumura, Yuko, Schneider, David, Deser, Clara, Wilson, Rob   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Surface accumulation in Northern Central Greenland during the last 300 years

Annals of Glaciology, 2020
The internal stratigraphy of snow and ice as imaged by ground-penetrating radar may serve as a source of information on past accumulation. This study presents results from two ground-based radar surveys conducted in Greenland in 2007 and 2015 ...
Nanna B. Karlsson, Sebastian Razik, Maria Hörhold, Anna Winter, Daniel Steinhage, Tobias Binder, Olaf Eisen   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Potential subglacial lake locations and meltwater drainage pathways beneath the Antarctic and Greenland ice sheets [PDF]

, 2013
We use the Shreve hydraulic potential equation as a simplified approach to investigate potential subglacial lake locations and meltwater drainage pathways beneath the Antarctic and Greenland ice sheets. We validate the method by demonstrating its ability
Clark, Chris, Woodward, J., Livingstone, Stephen, Woodward, John, Clark, C.D., Kingslake, J., Livingstone, S.J., Livingstone, S. J., Clark, C. D., J. Kingslake, Kingslake, Jonathan, C. D. Clark, S. J. Livingstone, J. Woodward   +13 more
core   +1 more source