Results 71 to 80 of about 3,287,043 (305)

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Characterizing Spatial Variability of Ice Algal Chlorophyll a and Net Primary Production between Sea Ice Habitats Using Horizontal Profiling Platforms

Frontiers in Marine Science, 2017
Assessing the role of sea ice algal biomass and primary production for polar ecosystems remains challenging due to the strong spatio-temporal variability of sea ice algae.
Benjamin A. Lange, Benjamin A. Lange, Christian Katlein, Giulia Castellani, Mar Fernández-Méndez, Mar Fernández-Méndez, Marcel Nicolaus, Ilka Peeken, Ilka Peeken, Hauke Flores, Hauke Flores   +10 more
doaj   +1 more source

Ice ages from ice core Taylor Dome

, 2006
Ice ages from ice core Taylor ...
Eric Monnin (7903829), Monnin, Eric
core   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Inferring palaeo-accumulation records from ice-core data by an adjoint-based method: application to James Ross Island's ice core [PDF]

Climate of the Past, 2015
Ice cores contain a record of snow precipitation that includes information about past atmospheric circulation and mass imbalance in the polar regions. We present a novel approach to reconstruct a climatic record – by both optimally dating an ice core and
C. Martín, R. Mulvaney, G. H. Gudmundsson, H. Corr   +3 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

50 year means of oxygen isotope data from ice core NGRIP

, 2007
Two deep ice cores from central Greenland, drilled in the 1990s, have played a key role in climate reconstructions of the Northern Hemisphere, but the oldest sections of the cores were disturbed in chronology owing to ice folding near the bedrock.
North Greenland Ice Core Project Members (7904567), North Greenland Ice Core Project Members   +1 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

An Evaluation of Antarctic Ice Core Nitrate Records as a Proxy for Solar Activity

Earth and Space Science
Nitrate (NO3−) deposition in polar ice sheets archives valuable information on past solar activity. However, interpretation of Antarctic ice core NO3− records as a proxy for past solar activity remains challenging due to multiple sources and processes ...
C. M. Laluraj, Rahaman Waliur, Thamban Meloth   +2 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source