Results 101 to 110 of about 1,022,984 (305)

Ice cores and SeaRISE: What we do (and don't) know [PDF]

Ice core analyses are needed in SeaRISE to learn what the West Antarctic ice sheet and other marine ice sheets were like in the past, what climate changes led to their present states, and how they behave.
Alley, Richard B.
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Decadal migration of Dome C inferred by global navigation satellite system measurements

Journal of Glaciology
Understanding the behaviour of domes under both contemporary and historical environmental conditions is essential to facilitate the study of dome-divide dynamics and the interpretation of ice core records.
Luca Vittuari, Antonio Zanutta, Stefano Gandolfi, Leonardo Martelli, Catherine Ritz, Stefano Urbini, Massimo Frezzotti   +6 more
doaj   +1 more source

A system for analysis of H₂ and Ne in polar ice core samples [PDF]

Atmospheric Measurement Techniques
This paper describes instrumentation and procedures developed to measure H2 and Ne in polar ice core samples. Gases are extracted from ice core samples by melting under vacuum.
E. S. Saltzman, E. S. Saltzman, M. H. Miranda, J. D. Patterson, M. Aydin   +4 more
doaj   +1 more source

A cold complex chemistry toward the low-mass protostar B1-b: evidence for complex molecule production in ices

, 2010
Gas-phase complex organic molecules have been detected toward a range of high- and low-mass star-forming regions at abundances which cannot be explained by any known gas-phase chemistry.
Bottinelli, Sandrine, Jorgensen, Jes K., Oberg, Karin I., van Dishoeck, Ewine F.   +3 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Anisotropic backscatter in ice-penetrating radar data: potential mechanisms and implications [PDF]

, 2010
Airborne and ground-based radar have been used extensively in the past to measure ice thickness and to investigate the internal structure of ice sheets in terms of layering.
Drews, Reinhard, Eisen, Olaf, Rack, Wolfgang, Steinhage, Daniel, Weikusat, Ilka   +4 more
core