Results 111 to 120 of about 1,022,984 (305)

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

10Be in the Akademii Nauk ice core – first results for CE 1590–1950 and implications for future chronology validation

Journal of Glaciology, 2017
Temporal variations of the radionuclide 10Be are broadly synchronous across the globe and thus provide a powerful tool to synchronize ice core chronologies from different locations.
LUISA VON ALBEDYLL, THOMAS OPEL, DIEDRICH FRITZSCHE, SILKE MERCHEL, THOMAS LAEPPLE, GEORG RUGEL   +5 more
doaj   +1 more source

Ice core analysis.

Journal of the Japanese Society of Snow and Ice, 1990
氷床コア解析のゴールは, 地球環境データの取得にあるが, それには氷床そのものの理解が基礎となる.コア解析の幾つかのトピックスとそれに関わる氷床過程の問題点を考えながら, コア解析の現状を簡単に紹介したい.
openaire   +2 more sources

Determination of crystal orientation fabric from seismic wideangle data [PDF]

, 2012
It is known from ice core analyses that the crystal orientation fabric (COF) of ice sheets is anisotropic and changes over depth. A better understanding of these anisotropies as well as their remote detection is important to optimize flow models for ice.
Bohlen, Thomas, Diez, Anja, Eisen, Olaf, Hofstede, Coen, Kipfstuhl, Sepp, Weikusat, Ilka   +5 more
core  

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Comparison of environmental conditions in the Bering Sea and Davis Strait and the effects on microwave signature returns; March and April, 1979 [PDF]

Aircraft data collected in the Bering Sea in March, 1979 using a 6.6 GH sub z (C Band) microwave radiometer and a 13.9 GH sub z (Ku Band) scatterometer, reinforce the difficulties in interpreting first year ice types found near the ice edge in a marginal
Martin, S., Mcnutt, S. L.
core   +1 more source

NFDI MatWerk Ontology (MWO): A BFO‐Compliant Ontology for Research Data Management in Materials Science and Engineering

Advanced Engineering Materials, EarlyView.
This article presents the NFDI‐MatWerk Ontology (MWO), a Basic Formal Ontology‐based framework for interoperable research data management in materials science and engineering (MSE). Covering consortium structures, research data management resources, services, and instruments, MWO enables semantic integration, Findable, Accessible, Interoperable, and ...
Hossein Beygi Nasrabadi, Ebrahim Norouzi, Kostiantyn Hubaiev, Jörg Waitelonis, Harald Sack   +4 more
wiley   +1 more source

Characteristics, origin and significance of chessboard subgrain boundaries in the WAIS divide ice core

Annals of Glaciology
Observation of thin sections of the WAIS (West Antarctic Ice Sheet) Divide ice core in cross-polarized light reveals a wealth of microstructures and textural characteristics indicative of strain and recovery in an anisotropic crystalline substance ...
Joan J. Fitzpatrick, Larry A. Wilen, Donald E. Voigt, Richard B. Alley, John M. Fegyveresi   +4 more
doaj   +1 more source