Results 121 to 130 of about 2,872,579 (294)

Tropical mountain ice core δ¹⁸O: A Goldilocks indicator for global temperature change. [PDF]

Sci Adv, 2023
Liu Z, Bao Y, Thompson LG, Mosley-Thompson E, Tabor C, Zhang GJ, Yan M, Lofverstrom M, Montanez I, Oster J.   +9 more
europepmc   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

First evidence of industrial fly-ash in an Antarctic ice core. [PDF]

Sci Rep, 2023
Thomas ER, Tetzner DR, Roberts SL, Turner SD, Rose NL.   +4 more
europepmc   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

A Tibetan ice core covering the past 1,300 years radiometrically dated with ³⁹Ar. [PDF]

Proc Natl Acad Sci U S A, 2022
Ritterbusch F, Tian L, Tong AM, Gu JQ, Jiang W, Lu ZT, Shao L, Tang MX, Yang GM, Zhang MJ, Zhao L.   +10 more
europepmc   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Greenland Ice Core Record of Last Glacial Dust Sources and Atmospheric Circulation. [PDF]

J Geophys Res Atmos, 2022
Újvári G, Klötzli U, Stevens T, Svensson A, Ludwig P, Vennemann T, Gier S, Horschinegg M, Palcsu L, Hippler D, Kovács J, Di Biagio C, Formenti P.   +12 more
europepmc   +1 more source

Ice-algal chlorophyll a and physical properties of multi-year and first-year sea ice of core CASIMBO-CORE-3_10

, 2015
Ice-algal chlorophyll a and physical properties of multi-year and first-year sea ice of core CASIMBO-CORE ...
Benjamin Allen Lange (6962450), Michel, Christine, Meisterhans, Guillaume, Ido Hatam (209666), Justin Beckers (6962453), Lange, Benjamin Allen, Haas, Christian, Niemi, Andrea, Hauke Flores (6979595), Hatam, Ido, Casey, J Alec, Andrea Niemi (8004593), Beckers, Justin, Christine Michel (8000204), Flores, Hauke, J Alec Casey (6962456), Christian Haas (6959543), Guillaume Meisterhans (728324)   +17 more
core   +1 more source

Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free‐Moving Mice

Advanced Healthcare Materials, EarlyView.
Application of a zwitterionic poly(sulfobetaine methacrylate) (PSB) coating to microelectrode arrays and Ag/AgCl reference electrodes effectively inhibits biofouling and structural degradation. This strategy successfully enables simultaneous, long‐term electrophysiological recording and dopamine sensing in freely behaving mice, facilitating ...
Bingchen Wu, Cort Thompson, Thomas Deakin, Yan Xu, Colleen A. McClung, Xinyan Tracy Cui   +5 more
wiley   +1 more source