Results 231 to 240 of about 815,112 (296)

m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6‐Mediated Wnt/β‐catenin Signaling Pathway

Advanced Science, EarlyView.
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao, Jian Zhang, Qi Qian, Min Jiang, Yu Liu, Yan Geng, Nan Cui, Qi Guo, Jie Guo   +8 more
wiley   +1 more source

High sea ice algal primary production near marine-terminating glaciers linked to turbulence-driven nutrient fluxes across the ice-ocean interface. [PDF]

Sci Rep
Søgaard DH, Rysgaard S, Vonnahme TR, Duarte P, Kudsk CE, Sorrell BK, Meire L, Verdugo J, Kristensen AD, Lever MA, Mortensen J, Lund-Hansen LC.   +11 more
europepmc   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

A continental-scale Eurasian ice sheet 2.4 million years ago. [PDF]

Nat Commun
Wagner K, Ylä-Mella L, Margold M, Knudsen MF, Sørensen AL, Larsen NK, Anderson RS, Eriksen BL, Olsen J, Andersen JL, Sláma J, Jansen JD.   +11 more
europepmc   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Dataset of a kilometer-scale meso-NH simulation for C2OMODO: The RCElarge300 collection of MesoNHforC2OMODO. [PDF]

Data Brief
Chaboureau JP.
europepmc   +1 more source

Psychrophilic Bacteria and Enzyme Activity in Antarctic Ice Environments. [PDF]

ACS Omega
Devecioglu D, Dikmetas DN, Neşe-Özcan G, Karbancioglu Guler F, Genceli Güner FE.   +4 more
europepmc   +1 more source

Hotspots of Arctic and sub-Arctic marine sediment organic carbon are dominated by the Baltic, Barents and Chukchi Seas. [PDF]

Commun Earth Environ
Langley B, Burdett HL, Cameron K, Juul-Pedersen T, Rouillard A, Slaymark C, Kamenos NA.   +6 more
europepmc   +1 more source

Ocean heat forced West Antarctic Ice Sheet retreat after the Last Glacial Maximum. [PDF]

Nat Commun
Mawbey EM, Smith JA, Hillenbrand CD, Hendry KR, McClymont EL, Greaves MJ, Klages JP, Kuhn G, Radionovskaya S, Spencer-Jones CL, Larter RD, Wellner JS, Dutrieux P.   +12 more
europepmc   +1 more source

Depth-resolved transcriptional activity of antibiotic resistance genes in deep permafrost of the Qinghai-Tibet Plateau. [PDF]

Commun Biol
Sajjad W, Kang S, Yin X, Wu X, Deng F, Williamson C, Rafiq M.   +6 more
europepmc   +1 more source