Results 101 to 110 of about 3,234 (297)
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Mechanical drill for deep coring in temperate ice
, 1974 A rotary drill for deep coring in temperate ice has been constructed and tested. The total length of the drill is 6 m and its weight is too kg. A steel armoured cable carries power to the 2 h.p, electric motor of the drill. The diameter of the core is 90
Björnsson Helgi +2 more
core +2 more sources
Geoscience Data JournalRecent decline of sea ice in the Barents Sea represents a clear manifestation of the ongoing Arctic warming. This study presents a compilation of data sets on sea ice physics acquired during 2018–2022 during Nansen Legacy—a Norwegian multidisciplinary ...
Dmitry V. Divine +9 more
doaj +1 more source
A newly developed snow vehicle (SM100S) for Antarctica I. Necessity and process of the development
Antarctic Record, 1992 Four types of snow vehicles have so far been employed in the Japanese Antarctic Research Expedition. These snow vehicles are mainly used on the inland ice sheet and on the sea ice.
Sadao Takeuchi +4 more
doaj +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source
The Pico Lightweight Coring Auger
, 1984 A new lightweight hand-operated coring auger for use in firn or ice is described. Extensive use of glass-epoxy composites contributes to a drill weight of approximately 1 kg/m in 20 m and 50 m configurations.
Bruce R. Koci, Karl C. Kuivinen
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Development of the U.S. deep coring ice drill
, 1994 P(論文)The United States has developed a deep coring ice drill capable of retrieving 13.2cm diameter cores 6m long. A comprehensive discussion of the developmental factors surrounding the design, fabrication and refinement of the United States 13.2cm deep ...
Wumkes, M. A.
core