Results 81 to 90 of about 3,234 (297)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Coring Planetary Ices; Their Thermomechanical Behaviour [PDF]
, 2002 Spacecraft missions are underway that will mechanically probe the material found at the surface of cometary nuclei. Little is known about the physical properties of these bodies and how their surface material will respond to a probe's sampling mechanisms.
Garry, James Robert Creighton
core +1 more source
What Lies Beneath? Interdisciplinary Outcomes of the ANDRILL Coulman High Project Site Surveys on the Ross Ice Shelf [PDF]
Oceanography, 2012 Extensive field operations were conducted on the northwestern Ross Ice Shelf in Antarctica from November 2010 through January 2011. A significant amount of equipment, supplies, and people safely traversed from McMurdo Station to establish a series of ...
Robert Zook +6 more
doaj
Development of the JARE deep ice coring system (II)
Antarctic Record, 1995 A deep ice coring system, which is to be used at Dome Fuji Station located at the summit of the Queen Maud Land ice sheet in 1995 and 1996,has been under development since 1988.
Hideki Narita +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
, 2020 We investigated the taxonomic composition and abundance of sea-ice meiofauna (here heterotrophs >10 µm) at eight ice stations on Arctic pack ice north of Svalbard. Sampling was conducted during spring in 2015 by sea-ice coring.
Peeken, Ilka +8 more
core +1 more source
Annals of GlaciologyObservation of thin sections of the WAIS (West Antarctic Ice Sheet) Divide ice core in cross-polarized light reveals a wealth of microstructures and textural characteristics indicative of strain and recovery in an anisotropic crystalline substance ...
Joan J. Fitzpatrick +4 more
doaj +1 more source