Results 71 to 80 of about 562,841 (289)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

First-year sea-ice salinity, temperature, density, oxygen and hydrogen isotope composition from the main coring site (MCS-FYI) during MOSAiC legs 1 to 4 in 2019/2020

, 2023
First-year sea-ice thickness, draft, salinity, temperature, and density were measured during near-weekly surveys at the main first-year ice coring site (MCS-FYI) during the MOSAiC expedition (legs 1 to 4). The ice cores were extracted either with a 9-cm (
Ulfsbo, Adam, Granskog, Mats A, Aguilar-Islas, Ana M, Torres-Valdés, Sinhué, Immerz, Antonia, Grosfeld, Lisa, Stefels, Jacqueline, Webster, Melinda, Vortkamp, Martina, Bowman, Jeff S, Whitmore, Laura M, Damm, Ellen, Salganik, Evgenii, Bozzato, Deborah, Chamberlain, Emelia, Abrahamsson, Katarina, Angelopoulos, Michael, Dumitrascu, Adela, Lange, Benjamin Allen, Fong, Allison A, Castellani, Giulia, D'Angelo, Alessandra, Eggers, Sarah Lena, Rinke, Annette, Olsen, Lasse Mørk, Spahic, Susanne, Gradinger, Rolf, Haapala, Jari, Marsay, Christopher M, Shimanchuk, Egor, Ren, Jian, Creamean, Jessie, Snoeijs-Leijonmalm, Pauline, Hoppe, Clara Jule Marie, Gardner, Jessie, Divine, Dmitry V, Kolabutin, Nikolai, Arndt, Stefanie, Lei, Ruibo, Maus, Sönke, Nuibom, Alexey, Verdugo, Josefa, Oggier, Marc, Wischnewski, Laura, Høyland, Knut Vilhelm, Balmonte, John Paul, Sheikin, Igor, Torstensson, Anders, Wang, Lei, Rember, Robert, Müller, Oliver, Fons, Steven W, Fong, Allison, University of Alaska Fairbanks, Alfred Wegener Institute, Whitmore, Laura, Univ Alaska, University of Alaska System, University of Alaska Fairbanks, Int Arctic Res Ctr, Bozzato, Deborah; id_orcid, Høyland, Knut V., Norwegian Polar Institute, Stefels lab, Stefels, Jacqueline; id_orcid   +61 more
core   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

The Second Deep Ice Coring at Dome Fuji, Antarctica.

Antarctic Record, 2020
The second deep ice coring project was carried out at Dome Fuji, Antarctica. Following the pilot hole drilling in 2001, deep ice core drilling was conducted for four years from the 2003/2004 austral summer season, reaching a depth of 3035.22 m in January
Hideaki Motoyama, Akiyoshi Takahashi, Yoichi Tanaka, Kunio Shinbori, Morihiro Miyahara, Takayasu Yoshimoto, Yoshiyuki Fujii, Toshitaka Suzuki, Teruo Furukawa, Kumiko Goto-Azuma, Keisuke Suzuki, Atsuhiro Muto, Makoto Igarashi, Tetsuhide Yamasaki, Shuji Fujta, Takeshi Saito, Genta Watanabe, Atsushi Furusaki, Yuanscheng Li, Chung Ji Woong, Kotaro Fukui, Fumio Nakazawa, Takao Kameda, Koji Fujita, Ichio Obinata, Takashi Saito, Kokichi Kamiyama, Jun Kinoshita, Nobuhiko Azuma, Yoshiki Nakayama, Okitsugu Watanabe, Morimasa Takata, Yukio Ozawa, Akio Kobayashi, Yasushi Yoshise   +34 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Sea-ice protist (including ice algae) abundance and biodiversity data from ice coring at the main coring sites (MCS_FYI and MCS_SYI) and ridges during MOSAiC legs 2 to 4 in 2019/2020

, 2023
The data has been collected during the expedition "Multidisciplinary drifting Observatory for the Study of Arctic Climate" (MOSAiC) from September 2019 to September 2020 on research vessel Polarstern.
Granskog, Mats A, Olsen, Lasse Mørk, Dąbrowska, Anna Maria, Gradinger, Rolf, Lange, Benjamin Allen, Tatarek, Agnieszka, Assmy, Philipp, Rozanska, Magdalena, Hoppe, Clara Jule Marie, Gardner, Jessie, Müller, Oliver, Divine, Dmitry V, Wiktor, Jozef M, Salganik, Evgenii   +13 more
core   +1 more source

Thermal Sidewall Ice Corer (TSIC) to recover samples from boreholes drilled in glaciers and ice sheets

Journal of Glaciology
The proposed Thermal Sidewall Ice Corer (TSIC) is designed to accurately sample horizontal ice layers of scientific interest, such as tephra layers, basal ice and shear zones, and retrieve ice cores back to the surface. The system features a bending core
Xianzhe Wei, Pavel G. Talalay, Da Gong, Yazhou Li, Xiaopeng Fan, Gaoli Zhao   +5 more
doaj   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source