Results 71 to 80 of about 24,371 (312)

Radio-Echo Sounding Over Polar Ice Masses [PDF]

, 2007
Peer reviewedPublisher ...
Bingham, Robert G., Siegert, Martin J.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Thermal Sidewall Ice Corer (TSIC) to recover samples from boreholes drilled in glaciers and ice sheets

Journal of Glaciology
The proposed Thermal Sidewall Ice Corer (TSIC) is designed to accurately sample horizontal ice layers of scientific interest, such as tephra layers, basal ice and shear zones, and retrieve ice cores back to the surface. The system features a bending core
Xianzhe Wei, Pavel G. Talalay, Da Gong, Yazhou Li, Xiaopeng Fan, Gaoli Zhao   +5 more
doaj   +1 more source

Development of the British Antarctic Survey Rapid Access Isotope Drill

Journal of Glaciology, 2019
The British Antarctic Survey Rapid Access Isotope Drill is an innovative new class of electromechanical ice drill, which has recently been used to drill the deepest dry hole drilled by an electromechanical auger drill. The record-breaking depth of 461.58
JULIUS RIX, ROBERT MULVANEY, JIALIN HONG, DAN ASHURST   +3 more
doaj   +1 more source

Microstructure mapping: a new method for imaging deformation-induced microstructural features of ice on the grain scale [PDF]

, 2006
This work presents a method of mapping deformation-related sublimation patterns, formed on the surface of ice specimens, at microscopic resolution (3-4 gm pixel(-1)).
Azuma, N., Faria, S. H., Freitag, Johannes, Grigoriev, D., Hamann, Ilka, Kipfstuhl, Sepp, Lambrecht, A.   +6 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Seismic modelling and paleoceanography at DSDP Site 574 [PDF]

, 1985
The analysis of high-resolution watergun seismic profiles collected in support of DSDP Leg 85 drilling reveals sev eral major, regionally traceable reflectors that can be correlated over more than 360,000 km2 in the central equatorial Pacific.
Mayer, Larry A., Shipley, Tom H., Theyer, Fritz, Wilkens, Roy H., Winterer, Edward L.   +4 more
core   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

What Lies Beneath? Interdisciplinary Outcomes of the ANDRILL Coulman High Project Site Surveys on the Ross Ice Shelf [PDF]

Oceanography, 2012
Extensive field operations were conducted on the northwestern Ross Ice Shelf in Antarctica from November 2010 through January 2011. A significant amount of equipment, supplies, and people safely traversed from McMurdo Station to establish a series of ...
Robert Zook, Frank R. Rack, Richard H. Levy, Richard Limeburner, Craig Stewart, Michael J.M. Williams, Bruce Luyendyk   +6 more
doaj