Results 51 to 60 of about 562,841 (289)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

RAM-2 Drill system development: an upgrade of the Rapid Air Movement Drill

Annals of Glaciology, 2021
Significant upgrades to the Rapid Air Movement (RAM) Drill were developed and tested by the US Ice Drilling Program in 2016 through 2020 for the U.S. National Science Foundation.
Christopher Gibson, Grant Boeckmann, Zachary Meulemans, Tanner Kuhl, Jim Koehler, Jay Johnson, Kristina Slawny   +6 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Air reverse circulation at the hole bottom in ice-core drilling

Journal of Glaciology, 2019
Ice-core drilling to depths of 200–300 m is an important part of research studies concerned with paleoclimate reconstruction and anthropogenic climate change. However, conventional drilling methods face difficulties due to firn permeability.
ZHENGYI HU, PAVEL TALALAY, ZHICHUAN ZHENG, PINLU CAO, GUITAO SHI, YUANSHENG LI, XIAOPENG FAN, HONGMEI MA   +7 more
doaj   +1 more source

New Seismic Methods to Support Sea-Ice Platform Drilling [PDF]

Scientific Drilling, 2009
The ANtarctic geological DRILLing Program (ANDRILL)is currently a consortium of five nations (Germany, Italy, New Zealand, the United Kingdom, a and the United States of America).
Stephen F. Pekar, David M. Harwood, Richard H. Levy, Marvin A. Speece, Ross D. Powell   +4 more
doaj   +1 more source

Antarctic subglacial drilling rig: Part II. Ice and Bedrock Electromechanical Drill (IBED)

Annals of Glaciology, 2021
A new, modified version of the cable-suspended Ice and Bedrock Electromechanical Drill (IBED) was designed for drilling in firn, ice, debris-rich ice and rock.
Pavel Talalay, Xingchen Li, Nan Zhang, Xiaopeng Fan, Youhong Sun, Pinlu Cao, Rusheng Wang, Yang Yang, Yongwen Liu, Yunchen Liu, Wei Wu, Cheng Yang, Jialin Hong, Da Gong, Han Zhang, Xiao Li, Yunwang Chen, An Liu, Yazhou Li   +18 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

High-resolution atmospheric CO2 record derived from the EPICA Dome C ice core covering MIS 9e - 12a

, 2020
High-resolution atmospheric CO2 data derived from the European Project for Ice Coring in Antarctica (EPICA) Dome C ice core covering Marine Isotope Stage (MIS) 9e ...
Grilli, Roberto, Nehrbass-Ahles, Christoph, Silva, Lucas, Teste, Grégory, Bereiter, Bernhard, Joos, Fortunat, Schmitt, Jochen, Schilt, Adrian, Shin, Jinhwa, Stocker, Thomas F, Fischer, Hubertus, Chappellaz, Jérôme A, Hodell, David A, Schmidely, Loïc   +13 more
core   +1 more source

Viability of chemical and water isotope ratio measurements of RAID ice chippings from Antarctica

Journal of Glaciology, 2023
The British Antarctic Survey's (BAS) Rapid Access Isotope Drill (RAID), designed for rapid drilling to survey prospective ice core sites, has been deployed at multiple Antarctic locations over 6 years.
Isobel F. Rowell, Robert Mulvaney, Julius Rix, Dieter R. Tetzner, Eric W. Wolff   +4 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source