Results 51 to 60 of about 481,486 (293)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Microstructure evolution of young sea ice from a Svalbard fjord using micro-CT analysis

Journal of Glaciology, 2022
We analysed the three-dimensional microstructure of sea ice by means of X-ray-micro computed tomography. Microscopic (brine- and air- pore sizes, numbers and connectivity) and macroscopic (salinity, density, porosity) properties of young Arctic sea ice ...
Martina Lan Salomon, Sönke Maus, Chris Petrich   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A laboratory investigation of ice cutting with a lightweigt electromechanical drill

Antarctic Record, 1988
A lightweight mechanical ice core drill of shallow depth capability was tested in a cold laboratory to obtain basic chracteristics of electromechanical drills in connection with a development of a deep ice core drilling system.
Yoshiyuki Fujii, Yoichi Tanaka, Hideki Narita, Moriatsu Miyahara, Akiyoshi Takahashi   +4 more
doaj   +1 more source

High-resolution aerosol data from the top 3.8 kyr of the East Greenland Ice coring Project (EGRIP) ice core [PDF]

, 2023
International audienceHere we present the high-resolution continuous flow analysis (CFA) data from the top 479 m of the East Greenland Ice coring Project (EGRIP) ice core covering the past 3.8 kyr.
Ogata, Jun, Segato, Delia, Adolphi, Florian, Maffezzoli, Niccoló, Hirabayashi, Motohiro, Darfeuil, Sophie, Mekhaldi, Florian, Jensen, Camilla Marie, Dallmayr, Remi, Scoto, Federico, Paleari, Chiara, Fukuda, Kaori, Burgay, François, Spagnesi, Azzurra, Behrens, Melanie, Kjaer, Helle Astrid, Kjær, Helle Astrid, Crotti, Ilaria, Muscheler, Raimund, Fischer, Hubertus, Twarloh, Birthe, Erhardt, Tobias   +21 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Core handling, transportation and processing for the South Pole ice core (SPICEcore) project

Annals of Glaciology, 2021
An intermediate-depth (1751 m) ice core was drilled at the South Pole between 2014 and 2016 using the newly designed US Intermediate Depth Drill. The South Pole ice core is the highest-resolution interior East Antarctic ice core record that extends into ...
Joseph M. Souney, Mark S. Twickler, Murat Aydin, Eric J. Steig, T. J. Fudge, Leah V. Street, Melinda R. Nicewonger, Emma C. Kahle, Jay A. Johnson, Tanner W. Kuhl, Kimberly A. Casey, John M. Fegyveresi, Richard M. Nunn, Geoffrey M. Hargreaves   +13 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Mineral dust variability in central West Antarctica associated with ozone depletion [PDF]

Atmospheric Chemistry and Physics, 2013
We present here data of mineral dust variability retrieved from an ice core of the central West Antarctic, spanning the last five decades. Main evidence provided by the geochemical analysis is that northerly air mass incursions to the coring site ...
M. Cataldo, H. Evangelista, J. C. Simões, R. H. M. Godoi, I. Simmonds, M. H. Hollanda, I. Wainer, F. Aquino, R. Van Grieken   +8 more
doaj   +1 more source