Results 51 to 60 of about 842,345 (240)

A Bayesian Logistic Regression for Probabilistic Forecasts of the Minimum September Arctic Sea Ice Cover

Earth and Space Science, 2020
This study introduces a Bayesian logistic regression framework that is capable of providing skillful probabilistic forecasts of Arctic sea ice cover, along with quantifying the attendant uncertainties.
Sean Horvath, Julienne Stroeve, Balaji Rajagopalan, William Kleiber   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Interannual variability of ice cover in the Caspian Sea

Journal of Hydrology X, 2022
Satellite remote sensing data (SAR and Ocean Color), MERRA-2 reanalysis and records at Astrakhan meteorological station were used to investigate interannual variability of ice cover characteristics in the North Caspian Sea for 23 winter seasons (November
Olga Yu. Lavrova, Anna I. Ginzburg, Andrey G. Kostianoy, Tatiana Yu. Bocharova   +3 more
doaj   +1 more source

Modern spatial sea-ice variability in the central Arctic Ocean and adjacent marginal seas: Reconstruction from biomarker data [PDF]

, 2012
Sea ice is a fundamental component of Earth’s climate system, contributing to heat reduction (albedo) and deep-water formation. In order to understand processes controlling the recent dramatic reduction in Arctic sea-ice cover, it is essential to ...
Fahl, Kirsten, Meheust, Marie, Müller, Juliane, Stein, Rüdiger, Xiao, Xiaotong   +4 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Method for Solving the Problem of Load Movement over the Ice Cover of a Reservoir along a Complex Trajectory

Advanced Engineering Research, 2023
Introduction. The development of the polar regions of the World Ocean contributed to an increased interest in studying wave processes in water bodies with ice cover caused by the action of a mobile load. In most papers of domestic and foreign scientists,
A. V. Galaburdin
doaj   +1 more source

The tipping times in an Arctic sea ice system under influence of extreme events

, 2020
In light of the rapid recent retreat of Arctic sea ice, the extreme weather events triggering the variability in Arctic ice cover has drawn increasing attention.
Duan, Jinqiao, Fu, Ling, Wiggins, Stephen, Yang, Fang, Zheng, Yayun   +4 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Analysis of ice phenology of lakes on the Tibetan Plateau from MODIS data [PDF]

The Cryosphere, 2013
The Tibetan Plateau includes a large system of endorheic (closed basin) lakes. Lake ice phenology, i.e. the timing of freeze-up and break-up and the duration of the ice cover may provide valuable information about climate variations in this region.
J. Kropáček, F. Maussion, F. Chen, S. Hoerz, V. Hochschild   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source