Results 81 to 90 of about 3,090,231 (345)

Subglacial Lake Ellsworth: a candidate for in situ exploration in West Antarctica [PDF]

, 2004
Radio-echo sounding reveals a 10 km-long lake beneath similar to3.4 km of ice near the Ellsworth Mountains in West Antarctica, 20 km from the ice divide. Subglacial Lake Ellsworth is located within a distinct topographic hollow, which is similar to1.5 km
Corr, H., Woodward, J., Payne, AJ, Joughin, I., King, Edward, Smith, Andrew, Siegert, MJ, King, E. C., Smith, A., Siegert, Martin J., Woodward, J, Hindmarsh, RCA, Corr, Hugh, Woodward, John, King, E, Payne, Antony J., Corr, H, King, Edward C., Payne, A. J., Hindmarsh, Richard, Joughin, Ian, Siegert, Martin, Siegert, M. J., Joughin, I, Smith, Andy, Smith, AM, Hindmarsh, R.   +26 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evaluation of Operation IceBridge quick-look snow depth estimates on sea ice

, 2015
We evaluate Operation IceBridge (OIB) ‘quick-look’ (QL) snow depth on sea ice retrievals using in situ measurements taken over immobile first-year ice (FYI) and multi-year ice (MYI) during March of 2014. Good agreement was found over undeformed FYI (-4.5
Joshua King, Richter-Menge, Jacqueline, Howell, Stephen, Kurtz, Nathan, Haas, Christian, Stephen Howell, Justin F. Beckers, Nathan Kurtz, Peter Toose, King, Joshua, Beckers, Justin, Chris Derksen, Nick Rutter, Christian Haas, Jacqueline Richter‐Menge, Toose, Peter, Rutter, Nick, Derksen, Chris   +17 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Late Quaternary ice-ocean interactions in central West Greenland [PDF]

, 2011
A greater knowledge of the interactions between the Greenland Ice Sheet and climate is critical to understanding the possible impacts of future global warming, including ice sheet contribution to global sea-level rise and perturbations to ocean ...
MCCARTHY, DAVID,JOHN, McCarthy, David John   +1 more
core  

Is Vostok lake in steady state? [PDF]

, 2004
Stable-isotope (D and 18O) data from the Vostok (East Antarctica) ice core are used to explore whether or not subglacial Vostok lake is in isotopic steady state. A simple box model shows that the lake is likely to be in steady state on time-scales of the
Royston-Bishop, G, Siegert, MJ, Tranter, M, Bates, PD, Lee, V, Bates, P. D., Siegert, M. J., Royston-Bishop, G., Tranter, M., Lee, V.   +9 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source