Results 141 to 150 of about 4,521,059 (346)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Deep Neural Network Based Scale‐Adaptive Cloud Vertical Overlap Parameterization

open access: yesGeophysical Research Letters
Cloud vertical overlap has important implications for cloud radiative effects in climate models. Due to its spatiotemporal complexity, it is difficult to simulate cloud overlap in climate models.
Xin Wu   +4 more
doaj   +1 more source

Diverse behaviors of marine ice sheets in response to temporal variability of the atmospheric and basal conditions

open access: yesJournal of Glaciology
The observed retreat of the grounding line of the present-day ice sheets and the simulated grounding-line retreat of ice sheets under changing climate conditions are often interpreted as indications of marine ice-sheet instability (MISI), driven by a ...
Olga Sergienko, Duncan John Wingham
doaj   +1 more source

Dynamical response of the southwestern Laurentide Ice Sheet to rapid Bølling–Allerød warming [PDF]

open access: yesThe Cryosphere
The shift in climate that occurred between the Last Glacial Maximum (LGM) and the Early Holocene (ca. 18–12 kyr BP) displayed rates of temperature increase similar to present-day warming trends.
S. L. Norris   +5 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Effective viscosity of grease ice in linearized gravity waves

open access: yes, 2004
Grease ice is an agglomeration of disc-shaped ice crystals, named frazil ice, which forms in turbulent waters of the Polar Oceans and in rivers as well.
de Carolis, Giacomo   +2 more
core   +1 more source

Glacitectonics – a key approach to examining ice dynamics, substrate rheology and ice-bed coupling

open access: yes, 2013
The role of ice masses within the Earth's climate system and in landscape change is increasingly being recognised within regions that are either currently glaciated or were glaciated during the geological past.
Jonathan R. Lee, E. Phillips
semanticscholar   +1 more source

Ice and Permafrost Effects on Delta Morphology and Channel Dynamics

open access: yesGeophysical Research Letters, 2019
Arctic regions are changing rapidly as permafrost thaws and sea ice retreats. These changes directly affect Arctic river deltas, but how permafrost and ice alter delta hydrology and sediment transport are not well researched.
R. Lauzon, A. Piliouras, J. Rowland
semanticscholar   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Diurnal Variation of Cloud Physical Properties for Tropical Cyclones Over North Atlantic in 2019–2023

open access: yesGeophysical Research Letters
Diurnal cloud variations critically modulate tropical cyclone (TC) precipitation and intensity, yet remain poorly understood due to the lack of continuous observations.
Cuiping Liu   +4 more
doaj   +1 more source

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