Results 121 to 130 of about 4,521,059 (346)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Thermodynamic effect dictates influence of the Atlantic Multidecadal Oscillation on Eurasia winter temperature

npj Climate and Atmospheric Science
The Atlantic Multidecadal Oscillation (AMO) has garnered attention for its important role in shaping surface air temperature (SAT) patterns over Eurasia.
Huan Wang, Zhiyan Zuo, Renhe Zhang, Li Peng, Kaiwen Zhang, Deliang Chen, Dong Xiao, Qinglong You, Guokun Dai, Ruonan Zhang, Haijun Yang, Xiaodan Chen, Zouxing Lin, Peiqiang Xu, Liang Qiao   +14 more
doaj   +1 more source

Treatment of the ice-shelf backpressure and buttressing in two horizontal dimensions

Journal of Glaciology
The ice discharge from the grounded parts of marine ice sheets into the ocean is modulated by their floating extensions – ice shelves. The ice-shelf impact on the grounded ice is typically described as ‘backpressure’ or ‘buttressing’.
Olga Sergienko
doaj   +1 more source

Evolution of the structure of amorphous ice - from low-density amorphous (LDA) through high-density amorphous (HDA) to very high-density amorphous (VHDA) ice

, 2005
We report results of molecular dynamics simulations of amorphous ice for pressures up to 22.5 kbar. The high-density amorphous ice (HDA) as prepared by pressure-induced amorphization of Ih ice at T=80 K is annealed to T=170 K at various pressures to ...
D. Donadio, Lindahl E., M. Parrinello, R. Martoňák   +3 more
core   +1 more source

Bioinspired Multifunctional Anti-icing Hydrogel [PDF]

, 2020
The recent anti-icing strategies in the state of the art mainly focused on three aspects: inhibiting ice nucleation, preventing ice propagation, and decreasing ice adhesion strength.
He, X, He, Z, Hua, M, Wang, J, Wu, C, Wu, D, Wu, S, Zhu, X   +7 more
core  

Coupled atmosphere-ice-ocean dynamics in Dansgaard-Oeschger events

Quaternary Science Reviews, 2019
The Dansgaard-Oeschger events of the last ice age are among the best studied abrupt climate changes, yet a comprehensive explanation is still lacking.
Camille Li, A. Born
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Hard rocks and deep wetlands beneath Thwaites Glacier in Antarctica

Communications Earth & Environment
Thwaites Glacier in West Antarctica is losing ice rapidly and is considered especially vulnerable to retreat, but predictions of its future remain limited by uncertainties about its subglacial properties.
Ole Zeising, Olaf Eisen, Coen Hofstede, Ronan Agnew, Alex Brisbourne, Andrew O. Hoffman, Sridhar Anandakrishnan, On behalf of the GHOST Team   +7 more
doaj   +1 more source

Environmental record of layers of bubbles in natural pond ice

Journal of Glaciology, 2018
Autonomous temperature data loggers were used to measure the temperature profile within a growing ice cover and in the water below. The ice formed under natural conditions over the pond.
JOLANA HRUBA, GUNTHER KLETETSCHKA
doaj   +1 more source