Results 101 to 110 of about 4,521,059 (346)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Influence of Hydrology on the Dynamics of Land-Terminating Sectors of the Greenland Ice Sheet

Frontiers in Earth Science, 2019
Coupling between runoff, hydrology, basal motion, and mass loss (“hydrology-dynamics”) is a critical component of the Greenland Ice Sheet system. Despite considerable research effort, the mechanisms by which runoff influences ice dynamics and the net ...
B. Davison, A. Sole, S. Livingstone, T. Cowton, P. Nienow   +4 more
semanticscholar   +1 more source

Structure and Dynamics of the Quasi-Liquid Layer at the Surface of Ice from Molecular Simulations

, 2018
We characterized the structural and dynamical properties of the quasi-liquid layer (QLL) at the surface of ice by molecular dynamics simulations with a thermodynamically consistent water model.
Donadio, Davide, Kling, Felix, Kling, Tanja   +2 more
core   +2 more sources

Entropy production and multiple equilibria: the case of the ice-albedo feedback [PDF]

, 2010
Nonlinear feedbacks in the Earth System provide mechanisms that can prove very useful in understanding complex dynamics with relatively simple concepts. For example, the temperature and the ice cover of the planet are linked in a positive feedback which ...
Dubrulle, Bérengère, Herbert, Corentin, Paillard, Didier   +2 more
core   +5 more sources

Dynamic Topography and Ice Age Paleoclimate

Annual Review of Earth and Planetary Sciences, 2020
The connection between the geological record and dynamic topography driven by mantle convective flow has been established over widely varying temporal and spatial scales. As observations of the process have increased and numerical modeling of thermochemical convection has improved, a burgeoning direction of research targeting outstanding issues in ice ...
Mitrovica, JX, Austermann, J, Coulson, S, Creveling, JR, Hoggard, MJ, Jarvis, GT, Richards, FD   +6 more
openaire   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Review article: Melt-affected ice cores for polar research in a warming world [PDF]

The Cryosphere
Melting polar and alpine ice sheets in response to global warming pose ecological and societal risks but will also hamper our ability to reconstruct past climate and atmospheric composition across the globe. Since polar ice caps are crucial environmental
D. E. Moser, D. E. Moser, E. R. Thomas, C. Nehrbass-Ahles, C. Nehrbass-Ahles, A. Eichler, A. Eichler, E. Wolff   +7 more
doaj   +1 more source

Dynamics of the Ice-Crushing Process [PDF]

Journal of Glaciology, 1988
AbstractDuring fast indentation tests on ice sheets at constant rates, crushing is commonly observed at appropriate combinations of speed and aspect ratio. An analysis is made of this mode of failure, using as a basis a recently conducted test on an ice sheet under controlled conditions.
Jordaan, Ian J., Timco, Garry W.
openaire   +2 more sources