Results 81 to 90 of about 192,513 (268)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Ice Model Tests for Dynamic Positioning Vessel in Managed Ice

Arctic Technology Conference, 2016
Abstract Stationkeeping in managed ice using dynamic positioning (DP) control system has been an area of great interest over the past few years. The stationkeeping performance of a DP vessel depends on the modelling accuracy of the ice forces, which in turn depends on managed ice field characteristics (floe size, floe thickness ...
Wang, Jungyong, Sayeed, Tanvir, Millan, David, Gash, Robert, Islam, Mohammed, Millan, James   +5 more
openaire   +2 more sources

Sea Ice Dynamics Drive Benthic Microbial Communities in McMurdo Sound, Antarctica. [PDF]

Front Microbiol, 2021
Currie AA, Marshall AJ, Lohrer AM, Cummings VJ, Seabrook S, Cary SC.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Changes in ice dynamics and mass balance of the Antarctic ice sheet [PDF]

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2006
The concept that the Antarctic ice sheet changes with eternal slowness has been challenged by recent observations from satellites. Pronounced regional warming in the Antarctic Peninsula triggered ice shelf collapse, which led to a 10-fold increase in glacier flow and rapid ice sheet retreat.
openaire   +4 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Deep Neural Network Based Scale‐Adaptive Cloud Vertical Overlap Parameterization

Geophysical Research Letters
Cloud vertical overlap has important implications for cloud radiative effects in climate models. Due to its spatiotemporal complexity, it is difficult to simulate cloud overlap in climate models.
Xin Wu, Feng Zhang, Hua Zhang, Haixia Xiao, Guoxing Chen   +4 more
doaj   +1 more source

Diverse behaviors of marine ice sheets in response to temporal variability of the atmospheric and basal conditions

Journal of Glaciology
The observed retreat of the grounding line of the present-day ice sheets and the simulated grounding-line retreat of ice sheets under changing climate conditions are often interpreted as indications of marine ice-sheet instability (MISI), driven by a ...
Olga Sergienko, Duncan John Wingham
doaj   +1 more source

Dynamical response of the southwestern Laurentide Ice Sheet to rapid Bølling–Allerød warming [PDF]

The Cryosphere
The shift in climate that occurred between the Last Glacial Maximum (LGM) and the Early Holocene (ca. 18–12 kyr BP) displayed rates of temperature increase similar to present-day warming trends.
S. L. Norris, S. L. Norris, M. Margold, D. J. A. Evans, N. Atkinson, D. G. Froese   +5 more
doaj   +1 more source