Results 71 to 80 of about 192,513 (268)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Retrieval of Cloud Macro‐Physical Properties Using theFY‐4A Advanced Geostationary Radiation Imager (AGRI) and the Geostationary Interferometric Infrared Sounder (GIIRS)

Geophysical Research Letters
This study presents a novel approach for conducting all‐day retrieval of cloud macro‐physical properties (single‐layer cloud phase, cloud top height, and cloud base height for optical thickness less than 10) using the Advanced Geostationary Radiation ...
Bin Guo, Feng Zhang, Zhijun Zhao, Jinyu Guo, Wenwen Li   +4 more
doaj   +1 more source

Treatment of the ice-shelf backpressure and buttressing in two horizontal dimensions

Journal of Glaciology
The ice discharge from the grounded parts of marine ice sheets into the ocean is modulated by their floating extensions – ice shelves. The ice-shelf impact on the grounded ice is typically described as ‘backpressure’ or ‘buttressing’.
Olga Sergienko
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Thermodynamic effect dictates influence of the Atlantic Multidecadal Oscillation on Eurasia winter temperature

npj Climate and Atmospheric Science
The Atlantic Multidecadal Oscillation (AMO) has garnered attention for its important role in shaping surface air temperature (SAT) patterns over Eurasia.
Huan Wang, Zhiyan Zuo, Renhe Zhang, Li Peng, Kaiwen Zhang, Deliang Chen, Dong Xiao, Qinglong You, Guokun Dai, Ruonan Zhang, Haijun Yang, Xiaodan Chen, Zouxing Lin, Peiqiang Xu, Liang Qiao   +14 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Environmental record of layers of bubbles in natural pond ice

Journal of Glaciology, 2018
Autonomous temperature data loggers were used to measure the temperature profile within a growing ice cover and in the water below. The ice formed under natural conditions over the pond.
JOLANA HRUBA, GUNTHER KLETETSCHKA
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

The significant influence of the Atlantic multidecadal variability to the abrupt warming in Northeast Asia in the 1990s

npj Climate and Atmospheric Science
Northeast Asia experienced unprecedented abrupt warming in the 1990s since the last century. Based on a robust time series and rank frequency evaluation, the Max Planck Institute for Meteorology Grand Ensembles of CMIP5 (MPI-GE5), CMIP6 (MPI-GE6), EC ...
Kaiwen Zhang, Zhiyan Zuo, Laura Suarez-Gutierrez, Lulei Bu   +3 more
doaj   +1 more source