Results 71 to 80 of about 3,816,888 (295)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A temperate former West Antarctic ice sheet suggested by an extensive zone of bed channels [PDF]

, 2014
We present radio-echo sounding data and satellite imagery, revealing a series of ancient large sub-parallel subglacial channels preserved in the region between the Möller and Foundation Ice Streams, West Antarctica.
Martin J. Siegert, Tom A. Jordan, Rippin, David M., Jordan, Tom A., Ross, N, Siegert, MJ, Corr, HFJ, Siegert, Martin J., Rippin, DM, Le Brocq, Anne, Hugh F.J. Corr, Jordan, TA, Kathryn C. Rose, Le Brocq, Anne M., Rose, Kathryn C., Bingham, RG, Le Brocq, AM, Anne M. Le Brocq, Ross, Neil, Fausto Ferraccioli, Rose, KC, Ferraccioli, F, Ferraccioli, Fausto, Corr, Hugh F.J., Robert G. Bingham, Neil Ross, David M. Rippin, Bingham, Robert G.   +27 more
core   +1 more source

Effects of excess ground ice on projections of permafrost in a warming climate

Environmental Research Letters, 2014
In permafrost soils, ‘excess ice’, also referred to as ground ice, exists in amounts exceeding soil porosity in forms such as ice lenses and wedges.
Hanna Lee, Sean C Swenson, Andrew G Slater, David M Lawrence   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Estimating biases during detection of leads and lags between climate elements across Dansgaard–Oeschger events [PDF]

Climate of the Past
Dansgaard–Oeschger (DO) events occurred throughout the last glacial period. Greenland ice cores show a rapid warming during each stadial to interstadial transition, alongside an abrupt loss of sea ice and a major reorganisation of the atmospheric ...
J. Slattery, J. Slattery, L. C. Sime, F. Muschitiello, K. Riechers, K. Riechers   +5 more
doaj   +1 more source

Ice-Sheet Dynamics

Annual Review of Fluid Mechanics, 2013
We describe the development of mathematical models of ice sheets, focusing on underlying physics and the minimal components that successful models must contain. Our review describes the basic fluid dynamical ice-flow models currently in use; points out numerous poorly understood thermomechanical feedbacks in ice flow; and describes the current, often ...
Schoof, C, Hewitt, I
openaire   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Review article: Melt-affected ice cores for polar research in a warming world [PDF]

The Cryosphere
Melting polar and alpine ice sheets in response to global warming pose ecological and societal risks but will also hamper our ability to reconstruct past climate and atmospheric composition across the globe. Since polar ice caps are crucial environmental
D. E. Moser, D. E. Moser, E. R. Thomas, C. Nehrbass-Ahles, C. Nehrbass-Ahles, A. Eichler, A. Eichler, E. Wolff   +7 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source