Results 51 to 60 of about 192,513 (268)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Modelling dynamic ice-sheet boundaries and grounding line migration using the level set method
Journal of Glaciology, 2020 Computing predictions of future sea level that include well-defined uncertainty bounds requires models that are capable of robustly simulating the evolution of ice sheets and glaciers.
M. Alamgir Hossain +2 more
doaj +1 more source
Ice Inheritance in Dynamical Disk Models
The Astrophysical Journal, 2021 Abstract The compositions of planet-forming disks are set by a combination of material inherited from the interstellar medium and material reprocessed during disk formation and evolution. Indeed, comets and primitive meteorites exhibit interstellar-like isotopic ratios and/or volatile compositions, supporting that some pristine material ...
Jennifer B. Bergner, Fred Ciesla
openaire +2 more sources
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The optimization method of wing ice shape regulation based on flight dynamics characteristics
Scientific Reports, 2022 Ice on aircraft wing changes the aircraft aerodynamic shape, and has negative effects on flight dynamic characteristics, seriously threatening flight safety. Plasma ice shape regulation is a new de-icing method.
Pengfei Dou +3 more
doaj +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Annual Review of Fluid Mechanics, 2013 We describe the development of mathematical models of ice sheets, focusing on underlying physics and the minimal components that successful models must contain. Our review describes the basic fluid dynamical ice-flow models currently in use; points out numerous poorly understood thermomechanical feedbacks in ice flow; and describes the current, often ...
Schoof, C, Hewitt, I
openaire +1 more source
Dynamics of Antifreeze Glycoproteins in the Presence of Ice [PDF]
Biophysical Journal, 2002 Antifreeze glycoproteins from the Greenland cod Boreogadus saida were dimethylated at the N-terminus (m*AFGP) and their dynamics and conformational properties were studied in the presence of ice using (13)C-NMR and FTIR spectroscopy. (13)C-NMR experiments of m*AFGP in D(2)O, in H(2)O, and of freeze-dried m*AFGP were performed as a function of ...
Tsvetkova, Nelly M. +8 more
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source