Results 111 to 120 of about 4,521,059 (346)

RIMBAY – a multi-approximation 3D ice-dynamics model for comprehensive applications: model description and examples

, 2014
. Glaciers and ice caps exhibit currently the largest cryospheric contributions to sea level rise. Modelling the dynamics and mass balance of the major ice sheets is therefore an important issue to investigate the current state and the future response of
M. Thoma, K. Grosfeld, D. Barbi, J. Determann, S. Goeller, C. Mayer, F. Pattyn   +6 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Estimating biases during detection of leads and lags between climate elements across Dansgaard–Oeschger events [PDF]

Climate of the Past
Dansgaard–Oeschger (DO) events occurred throughout the last glacial period. Greenland ice cores show a rapid warming during each stadial to interstadial transition, alongside an abrupt loss of sea ice and a major reorganisation of the atmospheric ...
J. Slattery, J. Slattery, L. C. Sime, F. Muschitiello, K. Riechers, K. Riechers   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cloud and ice in the planetary scale circulation and in climate [PDF]

The roles of the cryosphere, and of cloud-radiative interactions are investigated. The effects clouds and ice have in the climate system are examined.
Herman, G. F., Houghton, D. D., Kutzbach, J. E., Suomi, V. E.   +3 more
core   +1 more source

Melting dynamics of large ice balls in a turbulent swirling flow

, 2013
We study the melting dynamics of large ice balls in a turbulent von Karman flow at very high Reynolds number. Using an optical shadowgraphy setup, we record the time evolution of particle sizes.
Bianchi A. M., Boguslawski L., J. Bonaventure, N. Machicoane, R. Volk, Ranz W., Tennekes H.   +6 more
core   +1 more source

Emergent magnetic monopole dynamics in macroscopically degenerate artificial spin ice

Science Advances, 2019
We present direct, real-time observations of emergent magnetic monopole dynamics in highly frustrated artificial spin ice. Magnetic monopoles, proposed as elementary particles that act as isolated magnetic south and north poles, have long attracted ...
Alan Farhan, M. Saccone, Charlotte F. Petersen, S. Dhuey, R. Chopdekar, Yen-Lin Huang, N. Kent, Zuhuang Chen, M. Alava, T. Lippert, A. Scholl, S. van Dijken   +11 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Retrieval of Cloud Macro‐Physical Properties Using theFY‐4A Advanced Geostationary Radiation Imager (AGRI) and the Geostationary Interferometric Infrared Sounder (GIIRS)

Geophysical Research Letters
This study presents a novel approach for conducting all‐day retrieval of cloud macro‐physical properties (single‐layer cloud phase, cloud top height, and cloud base height for optical thickness less than 10) using the Advanced Geostationary Radiation ...
Bin Guo, Feng Zhang, Zhijun Zhao, Jinyu Guo, Wenwen Li   +4 more
doaj   +1 more source