Modelling dynamic ice-sheet boundaries and grounding line migration using the level set method
Journal of Glaciology, 2020 Computing predictions of future sea level that include well-defined uncertainty bounds requires models that are capable of robustly simulating the evolution of ice sheets and glaciers.
M. Alamgir Hossain +2 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The optimization method of wing ice shape regulation based on flight dynamics characteristics
Scientific Reports, 2022 Ice on aircraft wing changes the aircraft aerodynamic shape, and has negative effects on flight dynamic characteristics, seriously threatening flight safety. Plasma ice shape regulation is a new de-icing method.
Pengfei Dou +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Effects of excess ground ice on projections of permafrost in a warming climate
Environmental Research Letters, 2014 In permafrost soils, ‘excess ice’, also referred to as ground ice, exists in amounts exceeding soil porosity in forms such as ice lenses and wedges.
Hanna Lee +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Estimating biases during detection of leads and lags between climate elements across Dansgaard–Oeschger events [PDF]
Climate of the PastDansgaard–Oeschger (DO) events occurred throughout the last glacial period. Greenland ice cores show a rapid warming during each stadial to interstadial transition, alongside an abrupt loss of sea ice and a major reorganisation of the atmospheric ...
J. Slattery +5 more
doaj +1 more source
Thermodynamics and fractal dynamics of nematic spin ice, a doubly frustrated pyrochlore Ising magnet [PDF]
, 2023 Jonathan N. Hallén +2 more
openalex +1 more source