Results 51 to 60 of about 804,547 (290)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Multi-functional 2D hybrid aerogels for gas absorption applications

open access: yesScientific Reports, 2021
Aerogels have attracted significant attention recently due to their ultra-light weight porous structure, mechanical robustness, high electrical conductivity, facile scalability and their use as gas and oil absorbers.
Charalampos Androulidakis   +7 more
doaj   +1 more source

Engineering Properties of Fresh-Water Ice [PDF]

open access: yesJournal of Glaciology, 1977
AbstractThe principal engineering problems requiring knowledge concerning the properties of ice are prediction of the maximum force that ice might exert on a structure and determination of the load that can be placed safely on an ice cover. The properties of ice relevant to these problems are discussed.
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Strengthening ice through cyclic loading

open access: yesJournal of Glaciology, 2017
New experiments reveal that the flexural strength of fresh water, columnar-grained ice loaded normal to the columns may be increased by about a factor of two upon reversed cyclic loading at a frequency of ~0.1 Hz at stress amplitudes of 1.3–2.6 MPa.
DANIEL ILIESCU   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Engineering of frustration in colloidal artificial ices realized on microfeatured grooved lattices [PDF]

open access: yes, 2016
Artificial spin ice systems, namely lattices of interacting single domain ferromagnetic islands, have been used to date as microscopic models of frustration induced by lattice topology, allowing for the direct visualization of spin arrangements and ...
Ortiz-Ambriz, Antonio, Tierno, Pietro
core   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The 24 hour challenge: creating a multidiscipline environment for design and entrepreneurship in engineering and design. Enhancing Employability through Enterprise Education [PDF]

open access: yes, 2014
This Innovation and Creative Exchange (ICE) is an inter-school enterprise opportunity exclusively for second year Engineering and Design students at the University of Huddersfield.
Power, Jess
core  

Pr$_2$Ir$_2$O$_7$: when Luttinger semimetal meets Melko-Hertog-Gingras spin ice state

open access: yes, 2017
We study the band structure topology and engineering from the interplay between local moments and itinerant electrons in the context of pyrochlore iridates. For the metallic iridate Pr$_2$Ir$_2$O$_7$, the Ir $5d$ conduction electrons interact with the Pr
Chen, Gang, Yao, Xu Ping
core   +1 more source

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