Results 71 to 80 of about 2,466 (210)
Remote SensingThe Ku band microwave scatterometer (SCA) and scanning microwave radiometer (SMR) onboard HaiYang-2B (HY-2B) can simultaneously supply active and passive microwave observations over the polar region.
Tao Zeng +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Arctic sea ice decline contributes to thinning lake ice trend in northern Alaska
Environmental Research Letters, 2016 Field measurements, satellite observations, and models document a thinning trend in seasonal Arctic lake ice growth, causing a shift from bedfast to floating ice conditions. September sea ice concentrations in the Arctic Ocean since 1991 correlate well (
Vladimir A Alexeev +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Improving Predictions of Arctic Sea Ice Extent
Eos, 2015 Scientists in the Sea Ice Prediction Network share and discuss their user-oriented forecasts of seasonal sea ice in a changing Arctic.
Julienne Stroeve +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Interglacial ice extents of the Greenland ice sheet [PDF]
Past Global Changes Magazine, 2019 Carlson, Anders E., Larsen, Nicolaj Krog
openaire +3 more sources
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Atmosphere, 2019 In remote marine areas, biogenic productivity and atmospheric particulate are coupled through dimethylsulfide (DMS) emission by phytoplankton. Once in the atmosphere, the gaseous DMS is oxidized to produce H2SO4 and methanesulfonic acid (MSA); both ...
Silvia Becagli +13 more
doaj +1 more source