Results 51 to 60 of about 2,466 (210)

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sentinel-1 detection of ice slabs on the Greenland Ice Sheet [PDF]

The Cryosphere
Ice slabs are multi-meter-thick layers of refrozen ice that limit meltwater storage in firn, leading to enhanced surface runoff and ice sheet mass loss. To date, ice slabs have primarily been mapped using airborne ice-penetrating radar, which has limited
R. Culberg, R. J. Michaelides, J. Z. Miller   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Arctic sea ice minimum extent

Eos, Transactions American Geophysical Union, 2012
The extent of Arctic sea ice dropped to 3.41 million square kilometers on 16 September, 760,000 square kilometers below the minimum ice extent in 2007, which had been the low mark since the satellite record began in 1979, the National Snow and Ice Data Center (NSIDC) announced.
openaire   +1 more source

Antarctic Sea Ice—A Polar Opposite? [PDF]

Oceanography, 2012
As the world's ice diminishes in the face of climate change—from the dramatic decline in Arctic sea ice, to thinning at the margins of both the Greenland and Antarctic ice sheets, to retreating mountain glaciers the world over—Antarctic sea ice presents ...
Sharon E. Stammerjohn, Ted Maksym, Stephen Ackley, Rob Massom   +3 more
doaj  

Modeled Arctic sea ice evolution through 2300 in CMIP5 extended RCPs [PDF]

The Cryosphere, 2014
Almost all global climate models and Earth system models that participated in the Coupled Model Intercomparison Project 5 (CMIP5) show strong declines in Arctic sea ice extent and volume under the highest forcing scenario of the representative ...
P. J. Hezel, T. Fichefet, F. Massonnet
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Ice sheet extent and early deglacial history of the southwestern sector of the Greenland Ice Sheet [PDF]

Quaternary Science Reviews, 2009
The offshore and coastal geomorphology of southwest Greenland records evidence for the advance and decay of the Greenland Ice Sheet during the Last Glacial Maximum. Regional ice flow patterns in the vicinity of Sisimiut show an enlarged ice sheet that extended southwestwards on to the shelf, with an ice stream centred over Holsteinsborg dyb. High level
Roberts, D. H., Long, A. J., Schnabel, C., Davies, B., Simpson, M. J. R., Sheng, X., Huybrechts, P.   +6 more
openaire   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source