Results 31 to 40 of about 357,551 (214)
Winter sea ice export from the Laptev Sea preconditions the local summer sea ice cover and fast ice decay [PDF]
The Cryosphere, 2017 Ice retreat in the eastern Eurasian Arctic is a consequence of atmospheric and oceanic processes and regional feedback mechanisms acting on the ice cover, both in winter and summer.
P. Itkin, P. Itkin, T. Krumpen
doaj +1 more source
Remote Sensing, 2022 Three passive microwave-based sea ice products archived at the National Snow and Ice Data Center (NSIDC) are compared: (1) the NASA Team (NT) algorithm product, (2) Bootstrap (BT) algorithm product, and (3) a new version (Version 4) of the NOAA/NSIDC ...
Walter N. Meier +3 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Ice extent in sub-arctic fjords and coastal areas from 2001 to 2019 analyzed from MODIS imagery
Annals of Glaciology, 2020 Results examining variations in the ice extent along the Norwegian coastline based on the analysis of Moderate Resolution Imaging Spectroradiometer (MODIS) images from 2001 to 2019, February through May, are presented.
Megan O'Sadnick +3 more
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Record low 2022 Antarctic sea ice led to catastrophic breeding failure of emperor penguins
Communications Earth & Environment, 2023 The spring season of 2022 saw record low sea ice extent in Antarctica that persisted throughout the year. At the beginning of December, the Antarctic sea ice extent was tracking with the all-time low set in 2021. The greatest regional negative anomaly of
Peter T. Fretwell +2 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Environmental Research Letters, 2015 The rapid change in Arctic sea ice in recent decades has led to a rising demand for seasonal sea ice prediction. A recent modeling study that employed a prognostic melt pond model in a stand-alone sea ice model found that September Arctic sea ice extent ...
Jiping Liu +3 more
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Impacts of Observed Extreme Antarctic Sea Ice Conditions on the Southern Hemisphere Atmosphere
Atmosphere, 2022 The Antarctic sea ice has undergone dramatic changes in recent years, with the highest recorded sea ice extent in 2014 and the lowest in 2017. We investigated the impacts of the observed changes in these two extremes of Antarctic sea ice conditions on ...
Zhu Zhu, Mirong Song
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source