Results 41 to 50 of about 357,551 (214)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
MODIS-based Daily Lake Ice Extent and Coverage dataset for Tibetan Plateau
Big Earth Data, 2019 The Tibetan Plateau houses numerous lakes, the phenology and duration of lake ice in this region are sensitive to regional and global climate change, and as such are used as key indicators in climate change research, particularly in environment change ...
Yubao Qiu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Sentinel-1 detection of ice slabs on the Greenland Ice Sheet [PDF]
The CryosphereIce slabs are multi-meter-thick layers of refrozen ice that limit meltwater storage in firn, leading to enhanced surface runoff and ice sheet mass loss. To date, ice slabs have primarily been mapped using airborne ice-penetrating radar, which has limited
R. Culberg +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Regime Shift in Arctic Ocean Sea‐Ice Extent
Geophysical Research LettersA regime shift is an abrupt, substantial, and persistent change in the state of a system. We show that a regime shift in the September Arctic sea‐ice extent (SIE) occurred in 2007. Before 2007, September SIE was declining approximately linearly.
Harry L. Stern
doaj +1 more source
Antarctic Sea Ice—A Polar Opposite? [PDF]
Oceanography, 2012 As the world's ice diminishes in the face of climate change—from the dramatic decline in Arctic sea ice, to thinning at the margins of both the Greenland and Antarctic ice sheets, to retreating mountain glaciers the world over—Antarctic sea ice presents ...
Sharon E. Stammerjohn +3 more
doaj
Modeled Arctic sea ice evolution through 2300 in CMIP5 extended RCPs [PDF]
The Cryosphere, 2014 Almost all global climate models and Earth system models that participated in the Coupled Model Intercomparison Project 5 (CMIP5) show strong declines in Arctic sea ice extent and volume under the highest forcing scenario of the representative ...
P. J. Hezel, T. Fichefet, F. Massonnet
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source