Results 91 to 100 of about 102,397 (311)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Ice load penetration modelling

, 1987
POAC-87, 9th Port and Ocean Engineering under Arctic Conditions Conference, August 17, 1987, Fairbanks, Alaska, United ...
Riska, K., Frederking, R. M. W.
openaire   +1 more source

Acceleration of Late Pleistocene activity of a Central European fault driven by ice loading

, 2022
Petra Štěpančíková, T. Rockwell, Jakub Stemberk, Edward J. Rhodes, Filip Hartvich, Karen Luttrell, Madeline Myers, Petr Tábořík, Dylan H. Rood, Neta Wechsler, Daniel Nývlt, María Ortuño, Jozef Hók   +12 more
openalex   +2 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

A Framework for Structural Analysis of Icebreakers during Ramming of First-Year Ice Ridges

Journal of Marine Science and Engineering
This paper presents a framework for structural analysis of icebreakers during ramming of first-year ice ridges. The framework links the ice-ridge load and the structural analysis based on the physical characteristics of ship–ice-ridge interactions.
Weidong Zhao, Bernt Johan Leira, Knut Vilhelm Høyland, Ekaterina Kim, Guoqing Feng, Huilong Ren   +5 more
doaj   +1 more source

Numerical modeling of ice mechanical behavior under quasi-static and dynamic loads

, 2023
А.А. Родионов, С.В. Рябушкин   +1 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Research on Sea Ice and Local Ice Load Monitoring System for Polar Cargo Vessels

Journal of Marine Science and Engineering
Sea ice and the resulting loads are major safety concerns for vessels operating in ice-covered regions. This study presents a tailored sea ice and local ice load monitoring system specifically designed for polar cargo vessels.
Jinhui Jiang, Shuaikang He, Herong Jiang, Xiaodong Chen, Shunying Ji   +4 more
doaj   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source