Results 101 to 110 of about 565,318 (348)

Observed crustal uplift near the Southern Patagonian Icefield constrains improved viscoelastic Earth model [PDF]

, 2014
Thirty‒one GPS geodetic measurements of crustal uplift in southernmost South America determined extraordinarily high trend rates (> 35 mm/yr) in the north‒central part of the Southern Patagonian Icefield.
Casassa, G., Dietrich, R., Fritsche, M., Groh, A., Ivins, E. R., Lange, H., Richter, Andreas Jorg, Schroeder, L.   +7 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Fatigue Analysis for Shaft of Inland River Ship Under Ice Load

Journal of Marine Science and Engineering
Inland river ships navigating in an ice area cannot avoid contact between the propeller and ice block. In addition to ensuring the safety of propeller blades, the fatigue strength of the propulsion shaft system under ice load excitation must also be ...
Kai Yang, Guoqing Feng
doaj   +1 more source

Realistic Moving Ice Loads and Ship Structural Response [PDF]

, 2012
Prior work by the authors has shown that moving ice loads incite a significantly different structural response in steel grillage structures than do stationary ice loads. The work was based on a validated explicit numerical model of a steel grillage.
Daley, Claude, Gagnon, Robert, Quinton, Bruce   +2 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Response of IACS URI Ship Structures to Real-time Full-scale Operational Ice Loads [PDF]

, 2012
Moving ice loads can incite significantly different structural responses in a steel grillage structure than can stationary ice loads. This is significant because the accepted standard for the design and analysis of ice-classed ship structures is to ...
Daley, Claude, Gagnon, Robert, Quinton, Bruce   +2 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Numerical Simulation of Ice and Structure Interaction Using Common-Node DEM in LS DYNA

Journal of Marine Science and Engineering
In this work, the icebreaking performance of the cone structure was investigated using a new numerical model called the common-node DEM developed within LS DYNA.
Xiaolong Bai, Yin Jiang, Zhongxiang Shen, Renwei Liu, Zhen Liu   +4 more
doaj   +1 more source

Thresholds in the sliding resistance of simulated basal ice [PDF]

, 2007
We report laboratory determinations of the shear resistance to sliding melting ice with entrained particles over a hard, impermeable surface. With higher particle concentrations and larger particle sizes, Coulomb friction at particle-bed contacts ...
A. W. Rempel, L. F. Emerson
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source