Results 71 to 80 of about 47,826 (311)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Melting temperature changes during slip across subglacial cavities drive basal mass exchange

Journal of Glaciology, 2022
The importance of glacier sliding has motivated a rich literature describing the thermomechanical interactions between ice, liquid water and bed materials. Early recognition of the gradient in melting temperature across small bed obstacles led to focused
Alan W. Rempel, Colin R. Meyer, Kiya L. Riverman   +2 more
doaj   +1 more source

Full-scale runback ice: accretion and aerodynamic study [PDF]

, 2010
The runback ice phenomenon is well-known for anti-icing or de-icing systems when the system is not evaporating 100% of the water impinging the surface.
Alegre, Nathalie
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Seasonal evolution of granular and columnar sea ice pore microstructure and pore network connectivity

Journal of Glaciology, 2022
Sea-ice pore microstructure constrains ice transport properties, affecting fluid flow relevant to oil-in-ice transport and biogeochemical processes. Motivated by a lack of pore microstructural data, in particular for granular ice and across the seasonal ...
Marc Oggier, Hajo Eicken
doaj   +1 more source

Emergence of the Shackleton Range from beneath the Antarctic Ice Sheet due to glacial erosion [PDF]

, 2014
This paper explores the long-term evolution of a subglacial fjord landscape in the Shackleton Range, Antarctica. We propose that prolonged ice-sheet erosion across a passive continental margin caused troughs to deepen and lower the surrounding ice-sheet ...
Kerr, A. R., Hein, AS, Sugden, David, Stuart, F. M., Hein, A. S.; id_orcid, Sugden, DE, Fogwill, C. J., Kubik, PW, Kubik, P. W., Stuart, FM, Fogwill, CJ ; https://orcid.org/, Kerr, AR   +11 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

The generalized Clapeyron equation and its application to confined ice growth

Journal of Glaciology, 2023
Most theoretical descriptions of stresses induced by freezing are rooted in the (generalized) Clapeyron equation, which predicts the pressure that a solid can exert as it cools below its melting temperature.
Robert W. Style, Dominic Gerber, Alan W. Rempel, Eric R. Dufresne   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Increasing contribution of grain boundary compliance to polycrystalline ice elasticity as temperature increases

Journal of Glaciology, 2018
Measured elastic stiffnesses of ice polycrystals decrease with increasing temperature due to a decrease in grain boundary stiffness with increasing temperature.
COLIN M. SAYERS
doaj   +1 more source