Results 61 to 70 of about 386,787 (295)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Theory of the sea ice thickness distribution

, 2015
We use concepts from statistical physics to transform the original evolution equation for the sea ice thickness distribution $g(h)$ due to Thorndike et al., (1975) into a Fokker-Planck like conservation law. The steady solution is $g(h) = {\cal N}(q) h^q
Toppaladoddi, Srikanth, Wettlaufer, J. S.   +1 more
core   +1 more source

Numerical approximation of the Euler-Poisson-Boltzmann model in the quasineutral limit [PDF]

, 2010
This paper analyzes various schemes for the Euler-Poisson-Boltzmann (EPB) model of plasma physics. This model consists of the pressureless gas dynamics equations coupled with the Poisson equation and where the Boltzmann relation relates the potential to ...
A.B. Langdon, B.I. Cohen, D. Savelief, F. Bouchut, F. Bouchut, F.F. Chen, G.-Q. Chen, G.-Q. Chen, H. Liu, H. Liu, H. Liu, H. Liu, H.-H. Choe, L.T. Cheng, M.-H. Vignal, N.A. Krall, P. Crispel, P. Degond, P. Degond, P. Degond, P. Degond, P. Degond, P. Degond, Ph. Colella, R. Belaouar, R. Schneider, R.J. Leveque, R.J. Mason, R.J. Mason, S. Fabre, S. Jin, S. Jin, S. Jin, U. Shumlak, V.V. Rusanov, X. Li, Y. Brenier, Y. Brenier   +37 more
core   +6 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Dielectric anisotropy as indicator of crystal orientation fabric in Dome Fuji ice core: method and initial results

Journal of Glaciology, 2022
Polycrystalline ice is known to exhibit macroscopic anisotropy in relative permittivity (ɛ) depending on the crystal orientation fabric (COF). Using a new system designed to measure the tensorial components of ɛ, we investigated the dielectric anisotropy
Tomotaka Saruya, Shuji Fujita, Ryo Inoue
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Melting temperature changes during slip across subglacial cavities drive basal mass exchange

Journal of Glaciology, 2022
The importance of glacier sliding has motivated a rich literature describing the thermomechanical interactions between ice, liquid water and bed materials. Early recognition of the gradient in melting temperature across small bed obstacles led to focused
Alan W. Rempel, Colin R. Meyer, Kiya L. Riverman   +2 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Increasing contribution of grain boundary compliance to polycrystalline ice elasticity as temperature increases

Journal of Glaciology, 2018
Measured elastic stiffnesses of ice polycrystals decrease with increasing temperature due to a decrease in grain boundary stiffness with increasing temperature.
COLIN M. SAYERS
doaj   +1 more source

Seasonal evolution of granular and columnar sea ice pore microstructure and pore network connectivity

Journal of Glaciology, 2022
Sea-ice pore microstructure constrains ice transport properties, affecting fluid flow relevant to oil-in-ice transport and biogeochemical processes. Motivated by a lack of pore microstructural data, in particular for granular ice and across the seasonal ...
Marc Oggier, Hajo Eicken
doaj   +1 more source