Results 61 to 70 of about 2,598,475 (293)

Impact of surface nanostructure and wettability on interfacial ice physics

, 2021
LAMMPS data file and input script required to setup and run simulations carried out in the paper: Nikiforidis, Datta, Borg and Pillai, 'Impact of surface nanostructure and wettability on interfacial ice physics', Journal of Chemical ...
Datta, Saikat, Pillai, Rohit, Borg, Matthew Karl, Nikiforidis, Vasileios-Martin   +3 more
core   +2 more sources

The generalized Clapeyron equation and its application to confined ice growth

Journal of Glaciology, 2023
Most theoretical descriptions of stresses induced by freezing are rooted in the (generalized) Clapeyron equation, which predicts the pressure that a solid can exert as it cools below its melting temperature.
Robert W. Style, Dominic Gerber, Alan W. Rempel, Eric R. Dufresne   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Diffuse debris entrainment in glacier, lab and model environments

Annals of Glaciology, 2023
Small quantities of liquid water lining triple junctions in polycrystalline glacier ice form connected vein networks that enable material exchange with underlying basal environments. Diffuse debris concentrations commonly observed in ice marginal regions
Alan W. Rempel, Dougal D. Hansen, Luke K. Zoet, Colin R. Meyer   +3 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Boundary layer physics over snow and ice [PDF]

, 2007
Observations of the unique chemical environment over snow and ice in recent decades, particularly in the polar regions. have stimulated increasing interest in the boundary layer processes that mediate exchanges between the ice/snow interface and the ...
Anderson, P.S., W. D. Neff, Neff, W.D., Neff, W. D., P. S. Anderson, Anderson, P. S.   +5 more
core   +2 more sources

Description and validation of the ice-sheet model Yelmo (version 1.0) [PDF]

Geoscientific Model Development, 2020
We describe the physics and features of the ice-sheet model Yelmo, an open-source project intended for collaborative development. Yelmo is a thermomechanical model, solving for the coupled velocity and temperature solutions of an ice sheet simultaneously.
A. Robinson, A. Robinson, A. Robinson, J. Alvarez-Solas, J. Alvarez-Solas, M. Montoya, M. Montoya, H. Goelzer, H. Goelzer, R. Greve, R. Greve, C. Ritz   +11 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source