Results 61 to 70 of about 47,826 (311)

Short-term variability in Greenland Ice Sheet motion forced by time-varying meltwater inputs: implications for the relationship between subglacial drainage system behavior and ice velocity. [PDF]

, 2012
High resolution measurements of ice motion along a 120 km transect in a land-terminating section of the GrIS reveal short-term velocity variations (<1 day), which are forced by rapid variations in meltwater input to the subglacial drainage system from
Cowton, Thomas, Bartholomew, Ian, Nienow, Peter, Sole, A., Mair, Douglas, Mair, D., Sole, Andrew, King, Matt A., Cowton, T., Bartholomew, I., King, M.A., Nienow, P.   +11 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The concept of spin ice graphs and a field theory for their charges

AIP Advances, 2020
Originally detected in rare earth pyrochlores, spin ice physics is now being artificially extended to a variety of geometries that control collective behavior and exotic properties, making graph theory their proper framework.
Cristiano Nisoli
doaj   +1 more source

Ice Volume Characterization using Long-Wavelength Airborne PolSAR Data

, 2012
The interest in studying land ice for glaciological and climate change research has increased in recent years. The need of information on a global scale makes synthetic aperture radar (SAR) suitable for these studies.
Konstantinos P. Papathanassiou, Jagdhuber, Thomas, Papathanassiou, Konstantinos P., Hajnsek, Irena, Parrella, Giuseppe, Al-Kahachi, Noora, Papathanassiou, Kostantinos, Thomas Jagdhuber, Noora Al-Kahachi, Irena Hajnsek, Giuseppe Parrella   +10 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Atmospheric ice nuclei in the Eyjafjallajökull volcanic ash plume [PDF]

, 2011
Explosive volcanism affects weather and climate. Primary volcanic ash particles which act as ice nuclei (IN) can modify the phase and properties of cold tropospheric clouds.
B. Nillius, T. Herrmann, Levin, Zev, Curtius, Joachim, Nillius, Björn, M. Ebert, Bingemer, Heinz, S. Weinbruch, Haunold, Werner, Weber, A., H. Klein, Klein, Holger, Bundke, Ulrich, Weinbruch, Stephan, A. Wéber, Z. Levin, W. Haunold, D. Müller-Ebert, J. Curtius, K. Ardon-Dryer, Ebert, Martin, Judt, Anna, U. Bundke, Ardon-Dryer, Karin, H. Bingemer, A. Judt, Kandler, Konrad, Herrmann, Thomas, K. Kandler, Müller-Ebert, Dörthe   +29 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Dielectric anisotropy as indicator of crystal orientation fabric in Dome Fuji ice core: method and initial results

Journal of Glaciology, 2022
Polycrystalline ice is known to exhibit macroscopic anisotropy in relative permittivity (ɛ) depending on the crystal orientation fabric (COF). Using a new system designed to measure the tensorial components of ɛ, we investigated the dielectric anisotropy
Tomotaka Saruya, Shuji Fujita, Ryo Inoue
doaj   +1 more source

Impact of Variable Atmospheric and Oceanic Form Drag on Simulations of Arctic Sea Ice [PDF]

, 2014
Over Arctic sea ice, pressure ridges and floe and melt pond edges all introduce discrete obstructions to the flow of air or water past the ice and are a source of form drag.
Laxon, Seymour W., Farell, Sinead, Bacon, Sheldon, Schroeder, David, Kurtz, Nathan, Flocco, Daniela, Feltham, Daniel L., Tsamados, Michel, Farrell, Sinead L., Flocco, Dani, Feltham, Danny, Laxon, Seymour   +11 more
core   +1 more source