Results 111 to 120 of about 799,297 (341)

Sea ice colored by ice algae in a lagoon, Lake Saroma, Hokkaido, Japan

open access: yesAntarctic Record, 1981
The coloration of sea ice by the ice algae was studied at Mombetsu (44°20′N, 143°20′E) on the Okhotsk coast of Hokkaido and at Toetoko (44°11′N, 143°45′E) in a lagoon, Lake Saroma, which is also situated on the same coast, Hokkaido, Japan. Lake Saroma is
Takao Hoshiai, Mitsuo Fukuchi
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Effects of ice-wedge degradation and warming on Arctic tundra vegetation across a climatic gradient using a nitrogen-based model

open access: yesArctic, Antarctic, and Alpine Research
Ice-wedge polygons in Arctic tundra landscapes influence hydrology, nutrients, thermal regimes, and vegetation. Ice-wedges are particularly vulnerable to warming events, and widespread degradation has been observed in recent decades.
Kelcy Kent   +4 more
doaj   +1 more source

Identification of the ice‐binding face of a plant antifreeze protein

open access: yesFEBS Letters, 2009
The antifreeze protein of Lolium perenne, a perennial ryegrass, was previously modeled as a beta‐roll with two extensive flat beta‐sheets on opposite sides of the molecule. Here we have validated the model with a series of nine site‐directed steric mutations in which outward‐pointing short side‐chain residues were replaced by tyrosine.
Middleton, Adam J.   +3 more
openaire   +2 more sources

Reed Canarygrass in Alaska [PDF]

open access: yes, 1991
North American strains of reed canarygrass (Phalaris arundinacea L.) frequently sustain severe winter injury or total winterkill in southcentral Alaska.
Dofing, Stephen M.   +1 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Effect of cytoskeleton on ice crystal growth in cells during freezing

open access: yesInternational Journal of Food Properties, 2018
The factors affecting intracellular ice formation (IIF) and growth is essential to the mechanistic understanding of cellular damage through freezing. In the aid of high speed and high-resolution cryo-imaging technology, the broad bean intracellular ice ...
Yanqi Xie, Kai Zhu, Yabo Wang, Tong Chen
doaj   +1 more source

Heterogeneous Freezing of Liquid Suspensions Including Juices and Extracts from Berries and Leaves from Perennial Plants

open access: yesAtmosphere, 2019
Heterogeneous ice nucleation in the atmosphere is not fully understood. In particular, our knowledge of biological materials and their atmospheric ice nucleation properties remains scarce.
Laura Felgitsch   +6 more
doaj   +1 more source

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