Results 91 to 100 of about 3,077,712 (274)
The last glaciation of Shetland : local ice cap or invasive ice sheet? [PDF]
, 2014 Issue ISBN: 978-82-92-39488-5 This work is supported by the Carnegie Trust for the Universities of ScotlandThe question of whether the Shetland Islands were covered by an ice cap or by an ice sheet during the last glacial cycle (40–10 ka) remains ...
Hall, A. M.
core +2 more sources
Inositols affect the mating circadian rhythm of Drosophila melanogaster
Frontiers in Pharmacology, 2015 Accumulating evidence indicates that the molecular circadian clock underlies the mating behavior of D. melanogaster. However, information about which food components affect circadian mating behavior is scant.
Kazuki eSakata +10 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Sea ice colored by ice algae in a lagoon, Lake Saroma, Hokkaido, Japan
Antarctic Record, 1981 The coloration of sea ice by the ice algae was studied at Mombetsu (44°20′N, 143°20′E) on the Okhotsk coast of Hokkaido and at Toetoko (44°11′N, 143°45′E) in a lagoon, Lake Saroma, which is also situated on the same coast, Hokkaido, Japan. Lake Saroma is
Takao Hoshiai, Mitsuo Fukuchi
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Arctic, Antarctic, and Alpine ResearchIce-wedge polygons in Arctic tundra landscapes influence hydrology, nutrients, thermal regimes, and vegetation. Ice-wedges are particularly vulnerable to warming events, and widespread degradation has been observed in recent decades.
Kelcy Kent +4 more
doaj +1 more source
Effect of cytoskeleton on ice crystal growth in cells during freezing
International Journal of Food Properties, 2018 The factors affecting intracellular ice formation (IIF) and growth is essential to the mechanistic understanding of cellular damage through freezing. In the aid of high speed and high-resolution cryo-imaging technology, the broad bean intracellular ice ...
Yanqi Xie, Kai Zhu, Yabo Wang, Tong Chen
doaj +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source