Results 71 to 80 of about 3,077,712 (274)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 2020 This internet resource contains reports throughout the yearCOVID-19 Update Special Edition -- Original Plan for 2020 -- Kansas Cooperative Plant Disease Survey Report Preliminary 2020 Kansas Wheat Disease Loss ...
Kansas. Plant Protection and Weed Control Section
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 1915 Interior of the Palmetto Ice Plant, located on Elm Street, where the later Palmetto City Hall building was ...
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Displacement response to axial cycling of piles driven in sand [PDF]
, 2013 07.01.15 KB.
Rimoy, SP, Jardine, RJ, Standing, JR
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Inquiry into 'ice' use in the Northern Territory [PDF]
, 2015 Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT).Committee members -- Committee Secretariat -- Acknowledgments -- Acronyms and abbreviations -- Terms of reference -- Executive summary -- Recommendations -
Northern Territory Legislative Assembly. 'Ice" Select Committee
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
How Do Plants Survive Ice? [PDF]
Annals of Botany, 1996 Abstract Plant species have had to adapt to freezing and the presence of ice in many climatic zones. Annual plants avoid ice by seed dispersal but, for biennials and perennials to survive they must cope with ice in various forms. Most plants that are regularly exposed to ice during their life cycles have acquired a dormant or quiescent winter period,
openaire +1 more source