Results 61 to 70 of about 3,077,712 (274)
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Frontiers in Plant ScienceProgressive soil salinisation is a major constraint to agriculture, and deciphering resistance strategies in plants adapted to such harsh environments has the potential for improving salinity tolerance in crops. Efficient regulation of the photosynthetic
Maria Pilarska
doaj +1 more source
Anais da Academia Brasileira de Ciências, 2013 This work aims to summarize the results of research carried out by Brazilian researchers on the plant communities of Antarctic ice free areas during the last twenty five years.
ANTONIO B. PEREIRA, JAIR PUTZKE
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Vegetable ResearchCaryophyllales is one of the evolutionary branches of core eudicots, comprising numerous economically important species. However, comprehensive investigations into the genomic evolution of Caryophyllales remain scarce.
Shaoqin Shen +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Identification of the ice‐binding face of a plant antifreeze protein
FEBS Letters, 2009 The antifreeze protein of Lolium perenne, a perennial ryegrass, was previously modeled as a beta‐roll with two extensive flat beta‐sheets on opposite sides of the molecule. Here we have validated the model with a series of nine site‐directed steric mutations in which outward‐pointing short side‐chain residues were replaced by tyrosine.
Middleton, Adam J. +3 more
openaire +2 more sources
Toward a Molecular Understanding of Plant Hormone Actions [PDF]
, 2016 Plants rely on a diverse set of small-molecule hormones to regulate every aspect of their biological processes including development, growth, and adaptation. Since the discovery of the first plant hormone, auxin, hormones have always been at the frontier
Matsuoka, M. +23 more
core +1 more source
High interspecific variability in ice nucleation activity suggests pollen ice nucleators are incidental [PDF]
BiogeosciencesIce-nucleating macromolecules (INMs) produced by plant pollen can nucleate ice at warm temperatures and may play an important role in weather- and climate-relevant cloud glaciation.
N. L. H. Kinney +10 more
doaj +1 more source