Results 31 to 40 of about 360,583 (246)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Elastic-plastic responses of ship plates under ice impact loading
Zhongguo Jianchuan Yanjiu, 2020 Objectives Arctic channel plays an increasingly significant role in ocean transportation. Polar ships inevitably encounter ice floe impacts in the Arctic channel.
CAI Wei, ZHU Ling
doaj +1 more source
Numerical investigation of ice plate fractures upon rigid ball impact
Ocean Engineering, 2023 The fracture process and breaking capability of ice cover impacted by high-speed projectiles before underwater explosion is an urgent subject of scientific research in ice engineering applications. This paper presents the results of numerical simulations of the dynamic fracture behaviour induced by the impact of a small spherical projectile on an ice ...
Zhang, Yiheng +5 more
openaire +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
On the elasticity of ice plates
Canadian Journal of Civil Engineering, 1988 The rigidity modulus is determined for simply supported, circular ice plates 0.5 and 1.22 m in diameter. Measurements for the 0.5 m diameter plates were made at −10 °C and for the 1.22 m plates in the range of −7 to −37 °C. The elastic moduli and Poisson's ratio, calculated from the rigidity modulus, are in the range of 6.0–12.0 GPa and 0.29–0.60 ...
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Model test study on the extrusion action between plate frame structure and ice
Zhongguo Jianchuan YanjiuObjectivesAgainst the backdrop of global warming, maritime activities in the Arctic region are increasing, and polar vessels inevitably encounter ice loads during navigation.
Jiming LUO, Yuchao YUAN, Wenyong TANG
doaj +1 more source
Treatment of ice-shelf evolution combining flow and flexure
Journal of Glaciology, 2021 We develop a two-dimensional, plan-view formulation of ice-shelf flow and viscoelastic ice-shelf flexure. This formulation combines, for the first time, the shallow-shelf approximation for horizontal ice-shelf flow (and shallow-stream approximation for ...
Douglas R. MacAyeal +5 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source