Results 81 to 90 of about 316,907 (302)

Neoglacial cooling culminates in rapid sea ice oscillations in eastern Fram Strait [PDF]

, 2011
EGU2011-407 The spatial and temporal distribution of sea ice in the subpolar North Atlantic is mainly controlled by the advection of warm Atlantic Water via the Norwegian and West Spitsbergen Current in eastern Fram Strait.
Müller, Juliane, Spielhagen, Robert, Stein, Ruediger, Werner, Kirstin   +3 more
core  

Topological Sector Fluctuations and Curie Law Crossover in Spin Ice [PDF]

, 2012
At low temperatures, a spin ice enters a Coulomb phase - a state with algebraic correlations and topologically constrained spin configurations. In Ho2Ti2O7, we have observed experimentally that this process is accompanied by a non-standard temperature ...
Bramwell, Steven T., Fennell, Tom, Harris, Mark J., Holdsworth, Peter C. W., Jaubert, Ludovic D. C., Melko, Roger G.   +5 more
core   +5 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Zonal flow regimes in rotating anelastic spherical shells: an application to giant planets

, 2013
The surface zonal winds observed in the giant planets form a complex jet pattern with alternating prograde and retrograde direction. While the main equatorial band is prograde on the gas giants, both ice giants have a pronounced retrograde equatorial jet.
Aurnou, J. M., Gastine, T., Wicht, J.
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Combining Satellite, Teleconnection, and In Situ Data to Improve Understanding of Multi‐Decadal Coastal Ice Cover Dynamics on Earth's Largest Freshwater Lake

Earth and Space Science
To differentiate and understand drivers behind coastal ice cover trends and variability, we advance development of a model combining satellite, in situ, and teleconnection data along the shoreline of Earth's largest freshwater lake (Lake Superior ...
Manish Venumuddula, Karl Kirchner, Austin Chen, Richard B. Rood, Andrew D. Gronewold   +4 more
doaj   +1 more source

WATER AND ISE REGIME OF THE MAYMA RIVER (THE ALTAY MAUNTAINS) IN THE CONTEXT OF THE CURRENT CLIMATE CHANGE

Водное хозяйство России: проблемы, технологии, управление, 2019
The paper considers changes in the annual and seasonal runoff, as well as the ice regime of the Mayma River in response to changing climatic conditions in the catchment area during the period of 1940–2016.
Vladimir V. Zuev, Ekaterina M. Korotkova, Valeria A. Uymanova   +2 more
doaj   +1 more source

NATURAL ICE MOUNDS OF THE MIDDLE AND SOUTHERN SAKHALIN MUDFLOW BASINS

Водное хозяйство России: проблемы, технологии, управление, 2021
The article deals with the ice mounds formation processes in the mudflow basins. Small natural frosts are widespread on the territory of Middle and Southern Sakhalin within the slope and small valley debris flow basins, along with dangerous slope ...
Svetlana V. Rybalchenko, Konstantin V. Verkhovov   +1 more
doaj   +1 more source

Rain driven by receding ice sheets as a cause of past climate change [PDF]

, 2009
The Younger Dryas cold period, which interrupted the transition from the last ice age to modern conditions in Greenland, is one of the most dramatic incidents of abrupt climate change reconstructed from paleoclimate proxy records. Changes in the Atlantic
Bitz, Cecilia M., Eisenman, Ian, Tziperman, Eli   +2 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source