Results 81 to 90 of about 3,442,527 (297)

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Ice sheet model dependency of the simulated Greenland Ice Sheet in the mid-Pliocene [PDF]

Climate of the Past, 2015
Abstract. The understanding of the nature and behavior of ice sheets in past warm periods is important for constraining the potential impacts of future climate change. The Pliocene warm period (between 3.264 and 3.025 Ma) saw global temperatures similar to those projected for future climates; nevertheless, Pliocene ice locations and extents are still ...
Koenig, S., Dolan, A., de Boer, B., Stone, E., Hill, D., Deconto, R., Abe-Ouchi, A., Lunt, D., Pollard, D., Quiquet, A., Saito, F., Savage, J., van de Wal, R.   +12 more
openaire   +8 more sources

Past rates of accumulation in central West Antarctica [PDF]

, 2004
The spatial variation in ice accumulation is critical to the form and stability of ice sheets. In West Antarctica, knowledge of present ice accumulation rates is restricted to sparse measurements and interpolations across data free regions, while ...
Siegert, MJ, Payne, AJ, Siegert, Martin J., Payne, Antony J.   +3 more
core   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Error sources in basal yield stress inversions for Jakobshavn Isbræ, Greenland, derived from residual patterns of misfit to observations

Journal of Glaciology, 2017
The basal interface of glaciers is generally not directly observable. Geophysical inverse methods are therefore used to infer basal parameters from surface observations.
MARIJKE HABERMANN, MARTIN TRUFFER, DAVID MAXWELL   +2 more
doaj   +1 more source

Reconstructing ice dynamics in the central sector of the last British-Irish Ice Sheet [PDF]

, 2010
The central sector (NW England and Scottish borders) of the last British-Irish Ice Sheet exhibits a palimpsest glacial geological and geomorphological signature characteristic of multi-phase ice flow and ice-marginal fluctuations. Despite its influential
LIVINGSTONE, STEPHEN,JOHN, Livingstone, Stephen John   +1 more
core  

Short-term variability in Greenland Ice Sheet motion forced by time-varying meltwater inputs: implications for the relationship between subglacial drainage system behavior and ice velocity. [PDF]

, 2012
High resolution measurements of ice motion along a 120 km transect in a land-terminating section of the GrIS reveal short-term velocity variations (<1 day), which are forced by rapid variations in meltwater input to the subglacial drainage system from
Cowton, Thomas, Bartholomew, Ian, Nienow, Peter, Sole, A., Mair, Douglas, Mair, D., Sole, Andrew, King, Matt A., Cowton, T., Bartholomew, I., King, M.A., Nienow, P.   +11 more
core   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

A new ice sheet model validated by remote sensing of the Greenland ice sheet [PDF]

Open Geosciences, 2010
AbstractAccurate prediction of future sea level rise requires models that accurately reproduce and explain the recent observed dramatic ice sheet behaviours. This study presents a new multi-phase, multiple-rheology, scalable and extensible geofluid model of the Greenland ice sheet that shows the credential of successfully reproducing the mass loss rate
Ren, D., Fu, R., Karoly, D., Leslie, L., Chen, J., Wilson, C.   +5 more
openaire   +4 more sources

The response of a floating ice sheet to an accelerating line load [PDF]

, 2003
The two-dimensional response of a thin, floating sheet of ice to a line load that accelerates from rest at $t = 0$ to a uniform velocity V for $t \geq T$ is determined through an integral-transform solution of the linearized equations of motion.
Miles, J., Sneyd, Alfred D.
core   +1 more source